Heterocyclic derivatives useful as radiosensitizing agents and a

Details Heterocyclic derivatives useful as radiosensitizing agents and a Heterocyclic derivatives useful as radiosensitizing agents and a

1990-04-18

1991-11-12

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5482648, 424 11, A61K 3141, C07D24914

Patent

active

050648497

ABSTRACT:
A novel heterocyclic derivative of formula (I): ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2 represents hydrogen or acyl. When R.sub.2 is acyl, the derivative can be prepared, for example, by the following process: ##STR3## wherein R.sub.4 is acyl and R.sub.1 is ##STR4## The derivative is less toxic and has radiosensitizing activity and antiviral activity even at a low concentration.
Radiosensitizing agents and antiviral agents containing the derivative as active component are also disclosed.

REFERENCES:
patent: 4820844 (1989-04-01), Kogiya et al.
Takamura et al., "Polorographic Screening, Etc.", CA 110:208538d (1989).

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