Heterocyclic derivatives of DTPA used for magnetic resonance ima

Details Heterocyclic derivatives of DTPA used for magnetic resonance ima Heterocyclic derivatives of DTPA used for magnetic resonance ima

1990-01-23

1992-02-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 514184, 514836, G01N 3100, G01N 2400, A61K 31555

Patent

active

050874403

ABSTRACT:
Gadolinium and calcium chelates of DTPA (diethylenetriaminepentaacetic acid) bisamides, such as a composition comprising a gadolinium chelate of a 6-carboxymethyl-3,9-bis (hydroxyalkyl-carbamoylmethyl)-3,6,9-triazaundecanedioic acid and a calcium chelate of a 6-carboxymethyl-3,9-bis(hydroxyalkyl-carbamoylmethyl)-3,6,9- triazaundecanedioic acid, are disclosed for use as magnetic resonance imaging contrast media.

REFERENCES:
patent: 3480715 (1969-11-01), Catsch
patent: 3663688 (1972-05-01), Grotenhuis
patent: 4478816 (1984-10-01), Ledley et al.
patent: 4714607 (1987-12-01), Klaveness
patent: 4826673 (1989-05-01), Dean et al.
Weinmann et al., AJR142:619-624 (1984); "Characteristics of Gadolinium-DTPA Complex: A Potential NMR Contrast Agent".
Nalbandian et al., Ann. NY Acad Sci. (1959) pp. 779-792; "A New Category of Contrast Media: Water-Soluble Radiopaque Polyvalent Chelates".
Sapeika, BMJ, Jul. 16, (1955), pp. 167-169; "Radiographic Use of Lead E.D.T.A. In Man".
Runge et al., Investigative Radiology 19: pp. 408-415; "Paramagnetic NMR Contrast, Agents, Development and Evaluation", (1984).
Ovitt et al., University of Arizona Report No. PB272617 (1977); "Devices and Technology Branch, Division of Heart and Vascular Diseases".
Ovitt et al., University of Arizona Report No. PB8211888 (1979); "Devices and Technology Branch, Division of Heart and Vascular Diseases".
Shapiro et al., Ann. NY Acad, Sci. 78:756-757 (1959); "Heavy-Metal Chelates and Cesium Salts for Contrast Radiography".
Oser et al. Toxicology and Applied Pharmacology 5: 142-162 (1963); "Safety Evaluation Studies of Calcium EDTA".
Rubin et al., Science, 117:659-660 (1953).
Bessman et al., Med. Ann. DC, 21:312-315 (1952).
Belknap, Ind. Med. Surg., 21:305-306 (1952).
Catsch, Chem. Abst., 64:5413h (1966).
Lazlo, USAEC, Orins-12, 193-221 (1956).
Hart, USAEC, Orins-12, 118-135 (1956).
Lafuma, Proceedings of a Symposium on the Diagnostic Treatment of Deposited Radionuclides, (1967), 294-297.
Fried et al., Proc. Soc. Exptl. Biol. Med., 100:570-573 (1959).
Jones et al., J. Chem. Educ., 53:342-347 (1976).
Runge et al., Radiology, 153:171-176 (1984).
Kossakowski, Bull. Vet. Inst. Pulawy, 21:104-108 (1977).
Rosoff et al., Proceedings of the Fifteenth Annual Hanford Life Sciences Symposium, (1977), pp. 547-459.

Affiliated with

Also associated with

Rating

Heterocyclic derivatives of DTPA used for magnetic resonance ima does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic derivatives of DTPA used for magnetic resonance ima, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic derivatives of DTPA used for magnetic resonance ima will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-780753