Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-04-09
1995-06-27
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514241, 514318, 514326, 544180, 544217, 544219, 544295, 544360, 544364, 544369, 544370, 544372, 544379, 546194, 546207, 546208, 546209, 546210, 546213, 546214, 514241, 514318, 514326, A61K 31495, A61K 3153, A61K 31445, C07D25100, C07D40306, C07D41700, C07D41300, C07D41900
Patent
active
054280370
ABSTRACT:
Compounds of the formula: ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification or a pharmaceutically acceptable acid addition salt or N-oxide thereof, are calcium and sodium channel antagonists useful for treating mammals having a variety of disease states, such as stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and also for treatment of spinal injuries.
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patent: 5043447 (1991-08-01), Pascal et al.
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patent: 5252736 (1993-10-01), Pascal et al.
Katritzky, Handbook of Heterocyclic Chemistry (1985), p. 425.
Effects of KB-2796, a New Calcium Antagonist, and other Diphenylpiperazines on [.sup.3 H]Nitrendipine Binding, by T. Iwamoto et al., Japan J. Pharmacol. (1988), vol. 48, pp. 241-247.
Potential Antimalarials, by G. B. Barlin et al., Austr. J. Chem. (1990), vol. 43, pp. 1301-1307.
Blondet Dominique
Gellibert Francoise
McCort Gary
Pascal Jean-Claude
Lewis Brian
Syntex Pharmaceuticals Ltd.
Tsang Cecilia
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