Heterocyclic derivatives in the treatment of Ischaemia and relat

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514241, 514318, 514326, 544180, 544217, 544219, 544295, 544360, 544364, 544369, 544370, 544372, 544379, 546194, 546207, 546208, 546209, 546210, 546213, 546214, 514241, 514318, 514326, A61K 31495, A61K 3153, A61K 31445, C07D25100, C07D40306, C07D41700, C07D41300, C07D41900

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054280370

ABSTRACT:
Compounds of the formula: ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification or a pharmaceutically acceptable acid addition salt or N-oxide thereof, are calcium and sodium channel antagonists useful for treating mammals having a variety of disease states, such as stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and also for treatment of spinal injuries.

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patent: 5043447 (1991-08-01), Pascal et al.
patent: 5091428 (1992-02-01), Pascal et al.
patent: 5252736 (1993-10-01), Pascal et al.
Katritzky, Handbook of Heterocyclic Chemistry (1985), p. 425.
Effects of KB-2796, a New Calcium Antagonist, and other Diphenylpiperazines on [.sup.3 H]Nitrendipine Binding, by T. Iwamoto et al., Japan J. Pharmacol. (1988), vol. 48, pp. 241-247.
Potential Antimalarials, by G. B. Barlin et al., Austr. J. Chem. (1990), vol. 43, pp. 1301-1307.

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