Heterocyclic derivatives and radiosensitizing agents and antivir

Details Heterocyclic derivatives and radiosensitizing agents and antivir Heterocyclic derivatives and radiosensitizing agents and antivir

1988-09-21

1990-07-31

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548338, C07D23391, A61K 31415

Patent

active

049451022

ABSTRACT:
A novel heterocyclic derivative of formula (I): ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2 represents hydrogen or acyl. When R.sub.2 is acyl, the derivative can be prepared, for example, by the following process: ##STR3## wherein R.sub.4 is acyl and R.sub.1 is ##STR4## The derivative is less toxic and has radiosensitizing activity and antiviral activity even at a low concentration.
Radiosensitizing agents and antiviral agents containing the derivative as active component are also disclosed.

REFERENCES:
patent: 4462992 (1984-07-01), Agrawal et al.
Shibamoto et al., "Radiosensitization in Vitro, etc.", CA 105:186742h, (1986).
Murayama et al., "In Vitro and in Vivo, etc.", CA 107:150362m, (1987).
Kayaku, I, "Sensitization of Tumors by, etc.", CA 103:119002n, (1985).

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