Heterocyclic derivatives and medicinal use thereof

Details Heterocyclic derivatives and medicinal use thereof Heterocyclic derivatives and medicinal use thereof

2005-03-29

2005-03-29

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S147000

Reexamination Certificate

active

06872732

ABSTRACT:
The novel heterocyclic derivative of the present invention is a novel heterocyclic derivative having the formula (I′)wherein R1is a hydrogen atom or C1-6alkyl, R2is —CO—C(R4)═C(R4)—R5wherein R4is a hydrogen atom or C1-4alkyl, and R5is C4-8alkyl, C2-8alkenyl, aryl or aromatic heterocycle, —CO—C≡C—R6wherein R6is C1-8alkyl and the like, R3is a hydrogen atom or C1-4alkyl, X is an oxygen atom or a sulfur atom, R20is optionally substituted phenyl, and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof. The compound (I′) of the present invention is useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complications, a glucose tolerance improver, an anti-arteriosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated diseases and an agent for the prophylaxis or treatment of syndrome X.

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DATABASE XP-002239188, Bioorganic & Medicinal Chemistry, vol. 4, No. 1, 1994, pp. 57-62.
Heterocycles, 2001, vol. 55, No. 4, pp. 689-704.

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