Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-30
2005-08-30
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S253020, C514S253120, C514S254100, C544S238000, C544S295000, C544S360000
Reexamination Certificate
active
06936610
ABSTRACT:
The invention relates to heterocyclic derivatives of formula (I)in-line-formulae description="In-line Formulae" end="lead"?A—B—X1—T1(R2)—L1—T2(R3)—X2—Q (I)in-line-formulae description="In-line Formulae" end="tail"?or pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.
REFERENCES:
patent: 4167567 (1979-09-01), McCall
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4537896 (1985-08-01), Claeson et al.
patent: 4564610 (1986-01-01), Rahtz et al.
patent: 4629728 (1986-12-01), Regnier et al.
patent: 4788196 (1988-11-01), Cross et al.
patent: 4806536 (1989-02-01), Cross et al.
patent: 4835165 (1989-05-01), Cross et al.
patent: 4840963 (1989-06-01), Shepard et al.
patent: 4968704 (1990-11-01), Cross et al.
patent: 5032604 (1991-07-01), Baldwin et al.
patent: 5138058 (1992-08-01), Geisen et al.
patent: 5254563 (1993-10-01), Huth et al.
patent: 5332822 (1994-07-01), Misra
patent: 5364865 (1994-11-01), Diana
patent: 5371091 (1994-12-01), Misra et al.
patent: 5411971 (1995-05-01), Emonds-Alt et al.
patent: 5556977 (1996-09-01), Wayne et al.
patent: 5563141 (1996-10-01), Wayne et al.
patent: 5580881 (1996-12-01), Binet et al.
patent: 5606065 (1997-02-01), Emonds-Alt et al.
patent: 5681954 (1997-10-01), Yamamoto et al.
patent: 5795893 (1998-08-01), Bondinell et al.
patent: 5856326 (1999-01-01), Anthony et al.
patent: 6022869 (2000-02-01), Faull
patent: 6037343 (2000-03-01), Ali
patent: 10177/92 (1992-07-01), None
patent: 39 05 364 (1990-08-01), None
patent: 39 43 225 (1991-06-01), None
patent: 42 43 858 (1994-06-01), None
patent: 43 06 506 (1994-09-01), None
patent: 0 097 630 (1984-01-01), None
patent: 0 232 740 (1987-08-01), None
patent: 0 233 051 (1987-08-01), None
patent: 0 244 115 (1987-11-01), None
patent: 0 324 421 (1989-07-01), None
patent: 0 308 337 (1989-09-01), None
patent: 0 352 946 (1990-01-01), None
patent: 0 359 389 (1990-03-01), None
patent: 0 409 413 (1991-01-01), None
patent: 0 495 750 (1992-07-01), None
patent: 0 515 240 (1992-11-01), None
patent: 0 519 449 (1992-12-01), None
patent: 0 555 824 (1993-08-01), None
patent: 0 576 941 (1994-01-01), None
patent: 0 608 759 (1994-08-01), None
patent: 2 697 252 (1994-04-01), None
patent: 1 449 100 (1976-07-01), None
patent: 92/08706 (1992-05-01), None
patent: 92/18478 (1992-10-01), None
patent: 93/06085 (1993-04-01), None
patent: 94/18185 (1994-08-01), None
patent: 94/20467 (1994-09-01), None
patent: 94/20468 (1994-09-01), None
patent: 94/22835 (1994-10-01), None
patent: 96/05189 (1996-02-01), None
patent: 96/10022 (1996-04-01), None
patent: 96/26196 (1996-08-01), None
patent: 96/30343 (1996-10-01), None
patent: 96/33171 (1996-10-01), None
patent: 97/06802 (1997-02-01), None
patent: 97/28128 (1997-08-01), None
patent: 97/28129 (1997-08-01), None
patent: 97/29104 (1997-08-01), None
patent: 97/30971 (1997-08-01), None
patent: 98/06705 (1998-02-01), None
patent: 9/21188 (1998-05-01), None
Boissier et al., “Synthesis and Pharmacological Study of New Piperazine Derivatives . . . Benzylpiperazines”, J. Med. Chem., Sep. 1963, pp. 541-544.
Bowers Nemia et al., “Synthetic Routes to 3-Pyrrolidinol”, Synth. Comm. 13(13):1117-1123 (1983).
Budavari: Merck Index, vol. 11 ED., 1989, See Monograph Nos. 804 and 2807.
Cattel et al., “Drug design based on biosynthetic studies: synthesis, biological activity, and kinetics of new inhibitors of 2,3-oxidosqualene cyclase and squalene epoxidase”, Steroids, vol. 53, No. 3-5, 1989, pp. 363-391, XP000611661.
Caulkett et al., Chemical Abstracts. vol. 131:322629, 1999.
Chambers et al., “Preparation of arylpyridine compounds for treating leukotriene-related diseases”, Chemical Abstracts, Abstract No. 139113, vol. 119 (1993).
Conway et al., “Approaches to the Generation of 2,3-Indolyne”, Heterocycles, 1992, 34(11) pp. 2095-2108.
Cross et al., “Preparation of N-[(hetrocyclicylmethoxy)phenyl] sulfamides and analogs as antiarrhythmics”, Chemical Abstracts, Abstract No. 231211, vol. 113 (1989).
Deratani et al., “Synthesis of new dialkylaminopyridine acylation catalysts and their attachment to insoluble polymer supports”, Polymer, Apr. 1987, pp. 825-830.
Jucker, “Über C-substituierte Piperazinderativate”, Helv. Chim. Acta., 45:2383-2042 (1962).
Hibino et al., “N-Phenysulfonylindole derivatives”, Chemical Abstracts, 118:147461, Apr., 1993.
Jain et al., “Compounds Acting on the Central Nervous System, VII. Studies in 1-Pyridyl-1-substituted Piperazines. A New Class of Anticonvulsants”, J. Med. Chem., Sep. 1967, pp. 812-818.
Kataoka et al., Chemical Abstracts, vol. 123, No. 14, Oct. 2, 1995, Columbus, Ohio, U.S.; Abstract No. 179521d, “Homopiperazines as cell migration inhibitors”, XP002081582, see abstract & JP 95 145060 A (Tejin Ltd).
Kato et al., “Reactivities of 4-Chloropyridine Derivatives and Their 1-Oxides”, Chem. Pharm. Bull., 15:1343-1348 (1967).
Kato et al., “Studies on Ketene and Its Derivatives. LXXVI.1)Reactions of Acetoacetamide and β-Aminocrotonamide and β-Diketone, β-Ketoaldehyde and Related Compounds”, Chem. Pharm. Bull., 24(2):303-309 (1976).
Kobayashi et al., Chemical Abstracts, vol. 132:194391, 2000.
Mitsunobu et al., “Preparation of Carboxylic Esters and Phosphoric Esters by the Activation of Alcohols”, Bull. Chem. Soc. Jpn., 44(12):3427-3430 (1971).
Nowak et al., Chemical Abstracts, vol. 131:337034, 1999.
Kettner et al., “The Selective Inhibition of Thrombin by Peptides of Boroarginine”, The Journal of Biological Chemistry, vol. 265, No. 30, pp. 18289-18297 (1990).
Kobayashi et al., Chemical Abstracts, vol. 130:296694, 1999.
Prasad et al., “Antiamoebic Action of Drugs and Synthetic Compounds Against Trophozoites ofEntamoeba histolticaUnder Axenic and Polyxenic Culture Conditions and in the Infected Rat Caecum”, Curr. Sci., Aug. 1984, pp. 778-781.
Ratouis et al., “Synthesis and Pharmacological Study of New Piperazine Derivatives, II. Phenethylpiperazines”, J. Med. Chem., Jan. 1965, pp. 104-107.
Sartori et al., “Synthesis and analgesic activities of urea derivatives ofα-amino-N-pyridyl benzene propanamide”, Eur J. Med Chem (1994), pp. 431-439.
Sato et al., “Synthetic Studies on Cardiovascular Agents. III. Synthesis of Pyrano-[2,3-c]pyrazoline Derivatives”, Yakugaku Zasshi, vol. 98(3), 1978, pp. 335-348.
Saxena et al., “Quantitative Structure Activity Realtionship in 3-4 Disubstituted Pyridines & 1-(3″-Amino-4″pyridyl)-4-arylpiperazines”, Indian J. Chem., vol. 19B, Oct., 1980, pp. 873-878.
Smith et al., “Fibrin, Red Cell and Platelet Interactions in an Experimental Model of Thrombosis”, Br. J. Pharmac., vol. 77, pp. 29-38 (1982).
Sundberg et al., “Synthesis with N-Protected 2-Lithioindoles”, J. Org. Chem., 1973, 38(19) 3324-3330.
Szmant et al., “Concerning the Variable Character of the Sulfone Group”, J. Amer. Chem. Soc., vol. 78, pp. 3400-3403 (1956).
Tabacik et al., “Squalene expoxidase, oxido-squalene cyclase and cholesterol biosynthesis in normal and tumoral mucosa of the human gastrointestinal tract. Evidence of post-HMGACoA regulation”, Biochim. Biophys. Acta, vol. 666, No. 3, 1982, pp. 433-441, XP000610864.
Take et al., Chemical Abstracts, vol. 133:58814, 2000.
Tawada et al., Chemical Abstracts, vol. 130:38404, 1998.
Tawada et al., Chemical Abstracts, vol. 131:170361, 1999.
Vigroux et al., “Cyclization-Activated Prodrugs: N-(Substituted 2-hydroxyphenyl and 2-
Preston John
Rayner John Wall
Smithers Michael James
Stocker Andrew
Turner Paul
AstraZeneca UK Limited
Morgan & Lewis & Bockius, LLP
Raymond Richard L.
LandOfFree
Heterocyclic derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterocyclic derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3476745