Heterocyclic compounds useful as Nurr-1 activators

Details Heterocyclic compounds useful as Nurr-1 activators Heterocyclic compounds useful as Nurr-1 activators

2004-02-13

2008-10-07

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S125000, C548S131000, C548S215000, C548S235000, C548S236000, C514S361000, C514S374000

Reexamination Certificate

active

07432293

ABSTRACT:
The present invention relates to compounds of formula (I): wherein R1is hydroxy, C1-4alkoxy, amino, C1-4alkyl-amino, di C1-4alkylamino, benzyloxy or C2-C7alkanoyl, R2is C1-4alkyl, C1-4alkoxy, C1-4alkoxy C1-4alkoxy, CF3, halogen, C1-4alkylamino, di C1-4alkylamino, di C1-4alkylamino C1-4alkoxy or N—C1-4alkoxy C1-4alkyl-N—C1-4alkylamino, N—C1-4alkyl-piperazinyl, morpholinyl or pyrrolidinyl-C1-4alkoxy, wherein the C1-4alkyl radicals in R2are optionally further substituted by C1-4alkyl, halogen, cyano, amino, alkoxy or alkylthio, X is N or O, Y is N, O or CH, Z is N or CH, and W is N or CH, provided that (a) R1is not hydroxy or C1-4alkoxy when R2is CF3, X is O, Y is CH, Z is N and W is CH, (b) R1is not hydroxy or C1-4alkoxy when R2is CF3or chloro, X is N, Y is O, Z is CH and W is CH, (c) R1is not hydroxy when R2is CF3, X is O, Y is N, Z is CH and W is CH and (d) X and Y are not simultaneously O, the salts thereof; their preparation, their use and pharmaceutical compositions containing them.

REFERENCES:
patent: 6255327 (2001-07-01), Brenner et al.
patent: 6277872 (2001-08-01), Brenner et al.
patent: 6545009 (2003-04-01), Sugiyama et al.
patent: 7223791 (2007-05-01), Maekawa et al.
patent: 0 504 574 (2002-09-01), None

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