Heterocyclic compounds useful as growth hormone secretagogues

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S428000

Reexamination Certificate

active

11033649

ABSTRACT:
The present invention relates to novel heterocyclic compounds, according to Formula I, that stimulate endogenous production and/or release of growth hormone, wherein R1, R2, R3, R4and X are defined herein. Further, the present invention relates to methods for using such compounds and to pharmaceutical compositions containing such compounds

REFERENCES:
patent: 5622973 (1997-04-01), Morriello et al.
patent: 1 002 802 (2000-05-01), None
patent: WO 00/54729 (2000-09-01), None
Ankersen, M. et al., “Growth hormone secretagogues: recent advances and applications”, Drug Discovery Today, vol. 4, No. 11, pp. 497-506 (1999).
Svensson, J., “Growth hormone secretagogues”, Expert Opinion on Therapeutic Patents, vol. 10, No. 7, pp. 1071-1080 (2000).
Database CA 'Online! Chemical Abstracts Service, Columbus, Ohio, US, Kiyooka, Syunichi et al: “Synthesis of optically active beta-hydroxy acids having no substituent at alpha-position by aldol reaction” XP002336877 retrieved from STN Database accession No. 1985:5414126 RN 98352-25-1 abstract & Kochi Daigaku Rigakubu Kiyo, Kagaku, 6, 9-14 Coden: KDRKDD; ISSN: 0389-0279, 1985.

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