Heterocyclic compounds, their use and preparation

Details Heterocyclic compounds, their use and preparation Heterocyclic compounds, their use and preparation

1994-12-07

1996-09-24

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514250, 544337, 544343, 544346, 544354, 544356, 560 21, 564428, C07D48704, A61K 31495, A61K 31675, C07F 96524

Patent

active

055591060

ABSTRACT:
Quinoxaline compounds of the general formula ##STR1## wherein R.sup.1 is COX', POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently are hydroxy or alkoxy, and R.sup.6, R.sup.7, R.sup.8 and R.sup.9 independently are hydrogen, alkyl, halogen, NH.sub.2, NO.sub.2, CN, CF.sub.3, SO.sub.2 NY'Y" or COZ' wherein Z' is NY'Y" or alkyl and Y' and Y" independently are hydrogen or alkyl, triazolyl, imidazolyl, imidazolyl substituted with phenyl or alkyl, or R.sup.6 and R.sup.7, or R.sup.8 and R.sup.9, together form a further fused ring, are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters.

REFERENCES:
patent: 4354027 (1982-10-01), Loev et al.
McQuaid et al., J. Med. Chem., vol. 35, pp. 3319-3324 (1992).

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