Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-12-04
2008-10-21
Coleman, Brenda L (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S293000, C514S210050, C514S210080, C514S210100, C514S210120, C514S210130, C514S210150, C546S082000, C546S083000, C546S084000
Reexamination Certificate
active
07439253
ABSTRACT:
The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid:The invention also relates to a method for preparing these compounds, and to their use as medicaments, in particular as antibacterials and β-lactamase inhibitors.
REFERENCES:
patent: 5932587 (1999-08-01), Schmeck et al.
patent: 0 818 197 (1998-01-01), None
patent: 2 676 230 (1992-11-01), None
patent: WO 95/18129 (1995-07-01), None
patent: WO 00/00479 (2000-01-01), None
patent: WO 00/63187 (2000-10-01), None
patent: WO0210172 (2002-02-01), None
patent: WO02100860 (2002-12-01), None
patent: WO03063864 (2003-08-01), None
Chen et al, Synthesis of N-substituted 1,6-Dihydro-3(2H)-Pyridinones and 1-Acyl-3-Piperidones, Heterocycles, vol. 22, No. 12, 1984, pp. 2769-2773.
Hall, Jr. et al, 3-Isopropyl-1,3-diazabicyclo[3,3.1]nonan-2-one, a Simple Bicyclic Urea with a Bridgehead Nitrogen Atom, J. Org. Chem., vol. 37, Issue 5, 1972, pp. 697-699.
Hall, Jr. et al, Anti-Bredt Bridgehead Nitrogen Compounds in Ring-Opening Polymerization, Chemical Reviews, vol. 83, Issue 5, 1983, pp. 549-555.
Hall, Jr. et al, Anti-Bredt Molecules. 3.1a 3-Oxa-1-azabicyclo[3.3.1]nonan-2-one and 6-Oxa-1-azabicyclo[3.2.1]octan-7-one, two Atome-Bridged Bicyclic Uretyhanes Possessing Bridgehead Nitrogen, J. Org. Chem., vol. 45, Issue 26, 1980, pp. 5325-5326.
Itoh, Synthesis and Structure of 4-Substituted Decahydroisoquinoline Derivatives, Chem. Pharm. Bull., vol. 16, Issue 3, 1968, pp. 455-470.
Nicolaou et al, New Synthetic Technology for the Rapid Construction of Novel Heterocycles—Part 2. The Reaction of IBX with Anilides and Related Compounds, Chem. Int. Ed. 2000, vol. 39, Issue 3, 2000, pp. 625-628.
Pennington et al, Preparation and cyclization of substituted 1-anilino-3-halo-2- propanols and their conversion to indoles, Chem. Abs. RN 3189-20-6 and Journal of Organic Chemistry, vol. 30, No. 8, 1965, pp. 2801-1804.
Shiotanti et al, Studies on Diazabenzobicyclo[3.3.1]nonane System, M+1 Syntheses of 1,2,3,4-Tetrahydro-6H-1,5-methanobenzo[d] [1,2] diazocine Derivatives, Chemical Pharm. Bull., vol. 15, Issue 1, 1967, pp. 88-93.
Triebs, et al, Experiments for the preparation of azatropolones. I. Disubstituted 1-aza-4,5-cycloheptanedione and 5-azatropolone, Chem. Abs. RN 106478-62-0 and Journal Fuer Praktische Chemie (LEIPZIG), vol. 14, 1961, pp. 208-217.
Booker-Milburn, K.I. et al., “Azabenzocycloheptenones. Part 20. Synthesis and utilisation of 4-amino-1,2,3,4-tetrahydro-1(1H)-benzazepines,” J. Chem. Soc., Perkin Trans. 1: Organic and Bio-Organic Chemistry, pp. 3261-3273 (1997).*
Elliott, R. et al., “Syntheses and stereochemistry of 4-hydroxy tetrahydroisoquinolines in the 1-benzyl and 1-phenethyl series. Efficient routes to isopavines and homoisopavines,” Tetrahedron Letters, vol. 21, pp. 4633-4636 (1980).*
Heier, R.F. et al., “An asymmetric synthesis of (R)-5,6-dihydro-5-(methylamino)-4H-imidazo-[4,5,1-ij]quinolin-2(1H)-one and its [2-14C]- and [6,7-3H2]-labeled forms,” CAPLUS Database, Chemical Abstracts Service, Columbus, Ohio (1997).*
Heier, R.F. et al., “Synthesis and Biological Activities of (R)-5,6-Dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and Its Metabolites,” J. Med. Chem., vol. 40, pp. 639-646 (1997).*
Masumoto, S. et al., “Preparation of tricyclic quinazlinediones as poly (ADP-ribose) polymerase inhibitors,” CAPLUS Database, Chemical Abstracts Service, Columbus, Ohio (2001).*
Moon, M.W. et al., “Dopaminergic and Serotonergic Activities of Imidazoquiolinones and Related Compounds,” J. Med. Chem., vol. 35, pp. 1076-1092 (1992).*
Moon, M.W. et al., “Medicinal chemistry of imidazoquinolinone dopamine receptor agonists,” CAPLUS Database, Chemical Abstracts Service, Columbus, Ohio (1994).*
Moon, M.W. et al., “Synthesis of tritium-labeled (R)-5-(di[2,3-3H2]propylamino)-5,6-dihydro-4H-imidazo-[4,5,1-ij]quinolin-2(1H)-one([3H]U-86170) and (R)-5-([2,3-3H2]propylamino)-5,6-dihydro-4H-imidazo-[4,5,1-ij]quinolin-2(1H)-one([3H]U-91356),” CAPLUS Database, Chemical Abstracts Service, Columbus, Ohio (1993).*
Nagasaka, T. et al., “Preparation of 1,4-dihydro-4-phenyl-3,5-pyridinedicarboxylic acids as calcium antagonists,” CAPLUS Database, Chemical Abstracts Service, Columbus, Ohio (1994).*
Romero, A.G. et al., “Oxidative Cyclization of Acyclic Ureas with Bis(trifluoroacetoxy)iodobenzene to Generate N-Substituted 2-Benzimidazolinones,” Tetrahedron Letters, vol. 37, No. 14, pp. 2361-2364 (1996).*
Tirk, I. et al., “Hydroxyiminoisoquinolin-3(2H)-Ones, VI: Synthesis and Biological Activity of Some Aminoisoquinoline Derivatives,” Acto Chimica Hungarica, vol. 124, No. 2, pp. 195-207 (1987).*
Zhou, B. et al., “Studies Directed to the Total Synthesis of ET 743 and Analogues Thereof: An Expeditious Route to the ABFGH Subunit,” Org. Lett., vol. 4, No. 1, pp. 43-46 (2002).*
Klich Michel
Lampilas Maxime
Musicki Branislav
Rowlands David Alan
Coleman Brenda L
Harness & Dickey & Pierce P.L.C.
Novexel
LandOfFree
Heterocyclic compounds, their preparation and their use as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterocyclic compounds, their preparation and their use as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic compounds, their preparation and their use as... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3997123