Heterocyclic compounds, processes for their preparation and thei

Details Heterocyclic compounds, processes for their preparation and thei Heterocyclic compounds, processes for their preparation and thei

1980-06-27

1982-02-23

Siegel, Alan

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

549 60, 549 72, A61K 3138, C07D33324

Patent

active

043169074

ABSTRACT:
Thiophene carboxamides are described of general formula I ##STR1## in which the amide function is in the 2- or 3-position on the thiophene ring, R.sub.1 to R.sub.5 inclusive are hydrogen atoms or lower alkyl groups, X is --CH.sub.2 --, --O-- or --NR.sub.6 -- where R.sub.6 is hydrogen or a lower alkyl group, n is a number from 0 to 3 and Ar is an optionally substituted phenyl group
and their physiologically acceptable salts.
The compounds have been found to lower blood pressure in animals and to exhibit a blocking action at .beta.-adrenoreceptors and their use is indicated for the treatment of cardiovascular disorders such as hypertension and angina. Some of the compounds also exhibit a blocking action on .alpha.-adrenoreceptors and their use is indicated for the treatment of hypertention.

REFERENCES:
patent: 4024156 (1977-05-01), Bagli et al.
patent: 4082772 (1978-04-01), Bagli et al.
patent: 4085221 (1978-04-01), Smith
patent: 4086357 (1978-04-01), Large

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