Heterocyclic compounds having MMP and TNF inhibitory activity

Details Heterocyclic compounds having MMP and TNF inhibitory activity Heterocyclic compounds having MMP and TNF inhibitory activity

1998-11-12

2000-05-16

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544231, 544298, A61K 31513, C07D23922

Patent

active

060637862

ABSTRACT:
Compounds of formula (I) ##STR1## are useful as therapeutic agents, by virtue of having MMP and TNF inhibitory activity.

REFERENCES:
patent: 5750704 (1998-05-01), Shiokawa et al.
patent: 5847153 (1998-12-01), Warpehoski et al.
patent: 5872152 (1998-12-01), Brown et al.
Wine et al. Metalloproteinase inhibitors . . . Surgery 124, 464-470, 1998.
Hattori et al. Metalloproteinase inhibitors . . . Blood 90, 542-548, 1997.
Houghten et al. Bicyclic Guanidino Ketones, J. Org. Chem. 44, 4536-4543, 1979.
Fukada et al. Synthesis of . . . Synthesis 484-486, 1986.
Birkedal-Hansen et al. Matrix Metalloproteinases: A Review. Cricical Reviews in Oral Biology & Medicine 4(2) 197-250, 1993.
Bodanszky et al. The Practice of Peptide Synthesis. 138-143, 1994.

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