Heterocyclic compounds having MMP and TNF inhibitory activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544231, 544298, A61K 31513, C07D23922

Patent

active

060637862

ABSTRACT:
Compounds of formula (I) ##STR1## are useful as therapeutic agents, by virtue of having MMP and TNF inhibitory activity.

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Wine et al. Metalloproteinase inhibitors . . . Surgery 124, 464-470, 1998.
Hattori et al. Metalloproteinase inhibitors . . . Blood 90, 542-548, 1997.
Houghten et al. Bicyclic Guanidino Ketones, J. Org. Chem. 44, 4536-4543, 1979.
Fukada et al. Synthesis of . . . Synthesis 484-486, 1986.
Birkedal-Hansen et al. Matrix Metalloproteinases: A Review. Cricical Reviews in Oral Biology & Medicine 4(2) 197-250, 1993.
Bodanszky et al. The Practice of Peptide Synthesis. 138-143, 1994.

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