Heterocyclic compounds having inhibitory activity against...

Details Heterocyclic compounds having inhibitory activity against... Heterocyclic compounds having inhibitory activity against...

2008-04-15

2008-04-15

Seaman, Margaret D. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S253040, C514S300000, C546S122000, C544S127000, C544S362000

Reexamination Certificate

active

07358249

ABSTRACT:
A heterocyclic compound of the formula (I):wherein B1is —C(R2)═ or —N═; R1′ is H, etc.; one of R1and R2is -Z1-Z2-Z3-R5wherein Z1and Z3are independently single bond, optionally substituted alkylene, etc.; Z2is single bond, optionally substituted alkylene, etc.; R5is optionally substituted aryl, optionally substituted heteroaryl, etc., and the other of R1and R2is H; -A1- is —C(—Y)═C(—RA)—C(—R3)═C(—R4)—, etc. wherein Y is OH, etc.; RAis —COR7wherein R7is OH, etc.; one of R3and R4is carboxy, etc., and the other of R1and R2is H, etc,a prodrug thereof, a pharmaceutically acceptable salt thereof, and a solvate thereof, having an antiviral activity, more particularly, an inhibitory activity against HIV integrase, and a pharmaceutical composition containing the same, especially an anti-HIV drug.

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patent: 02/055079 (2002-07-01), None
patent: 02/070486 (2002-09-01), None
patent: 03/062204 (2003-07-01), None
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