Heterocyclic compounds having anti-diabetic activity and their u

Details Heterocyclic compounds having anti-diabetic activity and their u Heterocyclic compounds having anti-diabetic activity and their u

1996-09-13

1998-11-10

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514376, 548183, 548226, C07D26344, C07D27734, A61K 3142, A61K 31425

Patent

active

058345019

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxo-thiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxo-oxadiazolidin-2-ylmethyl or N-hydroxyureidom ethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and m is an integer of from 1 to 5 have hypoglycemic and anti-diabetic activities.

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The Ring Index--2nd Edition, Austin Patterson et al (America Chemical Society), p. 157 (1960).

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