Heterocyclic compounds as CCR5 antagonists

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C540S480000, C540S481000, C540S482000, C544S078000, C544S132000, C544S133000, C544S138000, C544S140000, C544S159000

Reexamination Certificate

active

07452992

ABSTRACT:
The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

REFERENCES:
patent: 6506750 (2003-01-01), Ducoux et al.
patent: 01031570 (1989-02-01), None
patent: WO 96/23787 (1996-08-01), None
patent: WO 00/58292 (2000-10-01), None
patent: WO 02/05819 (2002-01-01), None
patent: WO 02/079194 (2002-10-01), None
patent: WO 02/081449 (2002-10-01), None
patent: WO 02/094821 (2002-11-01), None
Ali et al.,Bioorg. Med. Chem. Lett. 11:819-822 (2001).
Edmonds-Alt et al.,The Journal of Pharmacology and Experimental Therapeutics303(3):1171-1179 (2002).
Nishi et al.,Bioorg. Med. Chem. Lett. 10:1665-1668 (2000).
Palani et al., “Discovery of 4-‘(Z)-(4-Bromophenyl)-(ethoxyimino)methyl !-1’-‘(2,4-dim ethyl-3-pyridinyl)carbonyl!-4’-methyl-1, 4'-bipiperidine N-Oxide (SCH351125): An orally bioavailable human CCR5 antagonist for the treatment of HIV infection,”Journal of Medicinal Chemistry44(21):3339-3342 (Oct. 2001).
Tyle, “Iontophoretic devices for drug delivery,”Pharmaceutical Research3(6):318-326 (1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Heterocyclic compounds as CCR5 antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic compounds as CCR5 antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic compounds as CCR5 antagonists will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4035518

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.