Heterocyclic compounds as aldose reductase inhibitors

Details Heterocyclic compounds as aldose reductase inhibitors Heterocyclic compounds as aldose reductase inhibitors

1990-04-05

1991-08-13

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540203, 548241, 548242, 548408, 548410, 549330, 549345, 549405, 560 31, 560 35, 560 39, 560 51, 560 53, 560 54, 560315, 562435, 562462, 564265, C07D49810, C07D491107, C07D48710, C07D31196

Patent

active

050396722

ABSTRACT:
Certain spirocyclic heterocyclic compounds, and their pharmaceutically-acceptable salts, are inhibitors of the aldose reductase enzyme, and so are useful for the control of diabetic complications. Exemplary compounds include compounds of the formula ##STR1## wherein Y is ##STR2## X is --O-- or ##STR3## R.sub.1 and R.sub.2 are each independently H, alkyl C.sub.1 -C.sub.6,aryl or arylalkyl (C.sub.1 -C.sub.6);

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