Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-03-18
2008-03-18
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S256000, C544S323000, C544S324000, C560S028000, C564S336000
Reexamination Certificate
active
10185059
ABSTRACT:
The invention relates to D-Ala-D-Ala ligase inhibitors having the formula:wherein R1is NH2; R2is NH2; R3is selected from hydrogen, alkyl, amino, hydroxy, alkoxy, and alkylamino; and R4and R4′are each independently hydrogen or a substituted or unsubstituted, linear, branched, or cyclic, alkyl, alkenyl, alkynyl, aryl, acyl, aralkyl, or alkaryl group wherein one or more carbon or hydrogen atoms may be substituted by a substituent selected from amino, alkylamino, hydroxyl, alkoxyl, thio, halogen, nitro, and carbonyl; wherein NR4R4′incorporates a substituted or unsubstituted naphthyl group, wherein the substituents are selected from alkoxy, halogen, alkyl, and alkylene, and wherein said naphthyl group in NR4R4′is bonded to N through a substituted or unsubstituted alkylene moiety. These compounds have antibacterial properties based on their ability to bind and inhibit D-Ala-D-Ala ligase, a critical pathway enzyme in bacterial cell-wall synthesis, and are suitable for various antibacterial uses.
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Ala Paul J.
Ali Janid A.
Clement Jacob J.
Connelly Patrick R.
Faerman Carlos H.
Berch Mark L.
Darby & Darby P.C.
Pliva D.D.
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