Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-03-18
2008-03-18
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S256000, C544S323000, C544S324000, C560S028000, C564S336000
Reexamination Certificate
active
07345048
ABSTRACT:
The invention relates to D-Ala-D-Ala ligase inhibitors having the formula:wherein R1is NH2; R2is NH2; R3is selected from hydrogen, alkyl, amino, hydroxy, alkoxy, and alkylamino; and R4and R4′are each independently hydrogen or a substituted or unsubstituted, linear, branched, or cyclic, alkyl, alkenyl, alkynyl, aryl, acyl, aralkyl, or alkaryl group wherein one or more carbon or hydrogen atoms may be substituted by a substituent selected from amino, alkylamino, hydroxyl, alkoxyl, thio, halogen, nitro, and carbonyl; wherein NR4R4′incorporates a substituted or unsubstituted naphthyl group, wherein the substituents are selected from alkoxy, halogen, alkyl, and alkylene, and wherein said naphthyl group in NR4R4′is bonded to N through a substituted or unsubstituted alkylene moiety. These compounds have antibacterial properties based on their ability to bind and inhibit D-Ala-D-Ala ligase, a critical pathway enzyme in bacterial cell-wall synthesis, and are suitable for various antibacterial uses.
REFERENCES:
patent: 2949466 (1960-08-01), Hoefle et al.
patent: 4256738 (1981-03-01), Woitun et al.
patent: 5593998 (1997-01-01), Henrie et al.
patent: 185 259 (1985-05-01), None
patent: 2000-239277 (2000-09-01), None
patent: 56210 (1974-04-01), None
patent: WO 92/17478 (1992-10-01), None
patent: WO 99/50264 (1999-10-01), None
patent: WO 2004/020417 (2004-03-01), None
Weinstock, J. Med. Chem 11(3), 1968, pp. 573-579.
Wang, Heterocycles 48(9) 1923 (1998).
Taylor, JACS 82, 5711 (1960).
Gangjee et al.,Bioorg Med Chem., Nov. 2001, 9(11):2929-2935, (abstract only).
Smith et al.,Clinical Cancer Research, Jul. 2001, 7:2105-2113.
Borhani et al.,Experimental Progress Reports, 1997, 7-105 to 7-107.
Wang, Heterocycles 48, 1923 (1998).
Weinstock, J Med Chem 11(3) 573 (1968).
Pettit, et al.,J. Carbohydrates, Nucleosides, Nucleotides, 7(5):315-332 (1980).
Hurlbert et al.,J Med Chem, 11(4):711-717 (Jul. 1968).
Elslager et al.,J Med Chem, 24(2):127-40 (Feb. 1981).
Chemical Abstracts 133:296425, (index entry for compound).
Chemical Abstracts 133:193165, (index entry for compound).
Ala Paul J.
Ali Janid A.
Clement Jacob J.
Connelly Patrick R.
Faerman Carlos H.
Berch Mark L.
Darby & Darby P.C.
Pliva D.D.
LandOfFree
Heterocyclic compounds and uses thereof as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterocyclic compounds and uses thereof as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic compounds and uses thereof as... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2804912