Heterocyclic compounds and uses thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S213000, C548S214000, C514S372000

Reexamination Certificate

active

06989451

ABSTRACT:
Substituted isothiazole compounds and compositions are provided, wherein particularly preferred compositions and methods are directed towards inhibition of various protein kinases (especially MEK and/or ERK). Consequently, particularly preferred methods include treatment of diseases associated with abnormality in MEK and/or ERK function.

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CA Registry No. 348137-52-0, entry date into Registry file on STN is Jul. 25, 2001.
CA Registry No. 348137-51-9, entry date into Registry file on STN is Jul. 25, 2001.
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CA Registry No. 287196-73-0, entry date into Registry file on STN is Aug. 24, 2000.
C.J. Shishoo, et al., “A Facile Synthesis of 3-Amino-5-substitutedaminiothiazole-4-carboxylic Acid Derivatives,” Dept. of Pharm. Chem., L.M. College of Pharmacy, p. 759-765, (Aug. 29, 1987).

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