Heterocyclic compounds and their use as angiotensin antagonists

Details Heterocyclic compounds and their use as angiotensin antagonists Heterocyclic compounds and their use as angiotensin antagonists

1998-12-08

2000-08-08

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514218, 514241, 514242, 514248, 514258, 514300, 514303, 514361, 514362, 514369, 514391, 514394, 544 68, 544179, 544221, 544238, 544300, 544310, 546 80, 546113, 546118, 5462774, 548122, 548132, 548135, 548144, 548181, 5482632, 5482646, 5483031, 5483037, 5483047, 5483061, 5483605, 540489, 540492, A61K 31535, A61K 3141, C07D41310, C07D41710, C07D49504

Patent

active

061002526

ABSTRACT:
##STR1## Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 5196444 (1993-03-01), Naka et al.
patent: 5210264 (1993-05-01), Conner et al.
patent: 5268375 (1993-12-01), Bernhart et al.
patent: 5354766 (1994-10-01), Naka et al.
patent: 5412097 (1995-05-01), Chakravarty et al.
patent: 5559233 (1996-09-01), Bernhart
patent: 5583141 (1996-12-01), Naka et al.

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