Heterocyclic compounds and their use as angiotensin antagonists

Details Heterocyclic compounds and their use as angiotensin antagonists Heterocyclic compounds and their use as angiotensin antagonists

1996-07-22

1998-04-07

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514291, 514361, 514364, 544236, 544280, 544281, 546 80, 546118, 548122, 548129, 548132, A61K 31435, A61K 3142, C07D47104, C07D28508

Patent

active

057365555

ABSTRACT:
##STR1## Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 5196444 (1992-03-01), Naka et al.
patent: 5268375 (1993-12-01), Bernhart et al.
patent: 5354766 (1994-10-01), Naka et al.
patent: 5412097 (1995-05-01), Chakravarty et al.
patent: 5559233 (1996-09-01), Bernhart et al.
patent: 5583141 (1996-12-01), Naka et al.

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