Heterocyclic compounds and methods of use

Details Heterocyclic compounds and methods of use Heterocyclic compounds and methods of use

2007-02-27

2007-02-27

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S419000, C548S235000, C548S492000

Reexamination Certificate

active

10495992

ABSTRACT:
Compounds of the formulaprovide pharmacological agents which are potent agonists of Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the treatment of conditions mediated by the PPAR receptor activity in mammals. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer's disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases, ulcerative colitis and Crohn's disease. The compounds of the present invention are particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions in which impaired glucose tolerance, hyperglycemia and insulin resistance are implicated, such as type-1 and type-2 diabetes, and Syndrome X. Preferred are the compounds of the invention which are dual agonists of PPARα and PPARγ receptors.

REFERENCES:
patent: 5036153 (1991-07-01), Braish et al.
patent: 5254543 (1993-10-01), Hanko et al.
patent: 5795890 (1998-08-01), Nakae et al.
patent: 0 769 498 (1997-04-01), None
patent: WO 92/03423 (1992-03-01), None
patent: WO 99/00387 (1999-01-01), None
patent: WO 99/32466 (1999-07-01), None
patent: WO 00/35442 (2000-06-01), None
patent: WO 00/50418 (2000-08-01), None
patent: WO 00/64888 (2000-11-01), None
Malamas et al., J. Med. Chem. No. 43, pp. 995-1010, New Azolidinediones as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties.

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