Heterocyclic compounds and anticancer-drug potentiaters conainin

Details Heterocyclic compounds and anticancer-drug potentiaters conainin Heterocyclic compounds and anticancer-drug potentiaters conainin

1991-12-03

1993-04-20

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514211, 514217, 514248, 514249, 514259, 514307, 514310, 514311, 514312, 514313, 514314, 540481, 540550, 540575, 540592, 544235, 544283, 544284, 544353, 544354, 544363, 546104, 546106, 546141, 546143, 546145, 546146, 546147, 546148, 546149, 546176, 546177, 546178, 546179, 546180, A61K 31495, A61K 3155, A61K 3147, C07D41100, C07D24308, C07D40100, C07D27110, C07D27762

Patent

active

052043487

ABSTRACT:
Novel heterocyclic compounds, which are represented by the following general formula, useful as anticancer drug potentiaters having a potentiating effect on the incorporation of anticancer drugs into cancer cells, the compounds each synthesized by, for example, reacting a epoxy compound obtained by reacting a heterocyclic compound with an epihalogenohydrin, with an amine derivative.

REFERENCES:
Takashi Tsuruo et al. Cancer Research 41, 1967-72 (1981).
Takashi Tsuruo et al. Cancer Research 44, 4303-07 (1984).
John Zamora et al., Molecular Pharmacology 33 454-462 (1988).
Ichiro Nogae et al., Biochemical Pharmacology 38(3) 519-527 (1989).
Norimasa Shudo et al., Cancer Research 50, 3055-3061 (1990).
Robert Pirker et al., Int. J. Cancer. 45, 916-19 (1990).
Johann Hofmann et al., Int. J. Cancer 47, 870-874 (1991).
K. Haubermann et al. European J. Clin. Pharmacol. (1991) 40, 53-59.
Ford et al., Molecular Pharmacology 35, 105-115, 1988.

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