Heterocyclic compounds

Details Heterocyclic compounds Heterocyclic compounds

1996-03-28

1998-02-10

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514217, 514324, 514325, 514422, 514423, 540550, 540591, 540592, 546202, 546204, 548525, 548528, C07D20712, C07D21142, A61K 3138, A61K 3140

Patent

active

057169497

ABSTRACT:
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

REFERENCES:
patent: 3968217 (1976-07-01), Helsley
patent: 3993757 (1976-11-01), Freedman
patent: 4181655 (1980-01-01), Barton et al.
patent: 5595989 (1997-01-01), Andersen et al.
Sindelar, et al., Collect. Czech. Chem. Commun., vol. 59, pp. 667-675, (1994).
Nakanishi, et al., Journal of Medicinal Chemistry, vol. 13, No. 4, pp. 664-648 (1970).
Sindelar et al., Antihistamine Substances. Tricyclic Analogues of N-(4,4-Diphenyl-3-butene-1-yl)Nipecotic Acid and some related compounds, Collect. Czech. Chem. Commun., vol. 59, pp. 667-674, 1994.

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