Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-11-04
2000-04-04
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514 43, 536 281, 546219, 546242, A01N 4340, A01N 4304, C07H 1900, C07D21140, C07D21136
Patent
active
060462140
ABSTRACT:
Novel piperidine compounds are provided, and those compounds are useful in the treatment and/or prevention of diabetes, and especially non-insulin dependent diabetes (NIDDM or type 2 diabetes) including overnight or meal treatment and treatment or prevention of longterm complications, such as retinopathy, neuropathy, nephropathy, and micro- and macroangiopathy; treatment of hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis or myocardial ischemia.
REFERENCES:
patent: 5844102 (1998-12-01), Sierks et al.
Ichikawa et al, Chemical Abstract vol. 123 No. 33550, "Foule Synthesis of Glucose Type 1-N-imino Sugars" 1995.
Ichikawa et al., (1998) J. Am. Chem. Soc. 120: 3007-3018.
Jespersen et al., (1994) Tetrahedron 50(47): 13449-13460.
Dong et al., (1996) Biochemistry 35:2788-2795.
Jespersen et al., (1994) Angew. Chem. 106(17):1858-1860.
Jakobsen Palle
Kristiansen Marit
Lundbeck Jane Marie
Lundgren Karsten
S.o slashed.kilde Birgitte
Covington Raymond
Novo Nordisk A S
Rotman Alan L.
Rozek Carol E.
Zelson Steven T.
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