Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-06-05
1993-08-03
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544223, A61K 4364, C07D48704
Patent
active
052329240
ABSTRACT:
A heterocyclic compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group, an aryl group which may be substituted with one or more substituents selected from the group consisting of a halogen atom, an alkoxy group, an alkyl group and a trihalogenomethyl group; .lambda. represents 0 or 1; ring A represents a 6 membered heterocyclic ring containing the nitrogen atom shared with the triazine ring and which may contain one or more double bonds; Y represents a substituted or unsubstituted alkylene group having 1 to 15 carbon atoms; and Q represents a group represented by formula (II): ##STR2## wherein R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are represented by substituents disclosed herein; or salt thereof, and intermediates therefor are described.
The compound of formula (I) or salt thereof exhibit selective serotonin 2-receptor antagonistic activity and are useful for the prevention or treatment of circulatory diseases, e.g., ischemic heart diseases, cerebral vessel disturbances, and peripheral circulation disturbances.
REFERENCES:
patent: 3609148 (1971-09-01), Hoegerle
"The Journal of Organic Chemistry", vol. 43, No. 25, 1978 Prisbe, E. J.; Verheyden, J. P. H.; Moffatt, J. G.
Morishima Yoshiyuki
Shibano Toshiro
Tanaka Tsuyoshi
Usui Hiroyuki
Watanabe Yoshifumi
Daiichi Pharmaceutical Co. Ltd.
Ramsuer Robert W.
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