Heterocyclic compound derivatives and medicines

Details Heterocyclic compound derivatives and medicines Heterocyclic compound derivatives and medicines

2007-04-17

2007-04-17

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S336000, C544S408000, C544S180000, C544S216000, C544S297000, C544S298000, C514S241000, C514S245000, C514S269000, C514S272000, C514S345000, C514S352000, C546S300000, C546S301000

Reexamination Certificate

active

10476196

ABSTRACT:
The present invention provides a compound which is useful as a PGI2receptor agonist, and a pharmaceutical composition.The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]:(R1and R2are the same or different and each represents optionally substituted aryl, Y represents N or CH, Z represents N or CH, A represents NH, NR5, O, S, or ethylene, R5represents alkyl, D represents alkylene or alkenylene, E represents phenylene or single bond, G represents O, S, or CH2, R3and R4are the same or different and each represents hydrogen or alkyl, Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, or N-(alkylsulfonyl)carbamoyl), or a pharmaceutically acceptable salt thereof as an active ingredient.

REFERENCES:
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Meanwell, Nicholas A. et al., Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety, J. Med. Chem., 1992, vol. 35, No. 19, pp. 3498 to 3512; particularly, compound Nos. 13aw, 13ax, 13aaa on table II.
Konno, Shoetsu et al., Studies on as-triazine derivatives. XIX. Synthesis of 2, 3-diarylpyrazine and 2, 3-diarypyridine derivatives as blood platelet aggregation inhibitors. Yakugaku Zasshi, 1993, vol. 113, No. 1, pp. 40 to 52; particularly, tables III, IV.
Bhalla, M. et al., Synthesis and pharmacological evaluation of 1, 2, 4-triazine and its congeners, Boll. Chim. Farm., 1995, vol. 134, No. 1, pp. 9 to 15; compounds on formulas IV, V of Fig. 1.

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