Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-11
2007-12-11
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S112000, C544S114000
Reexamination Certificate
active
11478647
ABSTRACT:
The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components:wherein X represents nitrogen atom or CH; R1represents CHnF3-n(wherein n is 1 or 2), hydroxy C1-C6alkyl, NHR6[wherein R6represents hydrogen atom or COR (wherein R represents hydrogen atom, C1-C6alkyl or C1-C6alkoxy)]; R2represents morpholino (which may be substituted with one to four C1-C6alkyl), thiomorpholino, piperidino, pyrrolidinyl (which may be substituted with hydroxy C1-C6alkyl), oxazolidinyl (which may be substituted with one or two C1-C6alkyl) or tetrahydro-1,4-thiazin-1-oxo-4-yl; R3and R4each represent hydrogen atom or C1-C6alkyl; and R5represents hydrogen atom, amino or hydroxyl.
REFERENCES:
patent: 3308122 (1967-03-01), Tolkmith
patent: 5489591 (1996-02-01), Kobayashi et al.
patent: 5852019 (1998-12-01), Ejima et al.
patent: 6251900 (2001-06-01), Kawashima et al.
patent: 7071189 (2006-07-01), Kawashima et al.
patent: 2004/0116421 (2004-06-01), Kawashima et al.
patent: 2006/0009440 (2006-01-01), Kawashima et al.
patent: 0 240 854 (1987-10-01), None
patent: 0 640 599 (1995-03-01), None
patent: 49-17677 (1974-05-01), None
patent: 56-55302 (1981-05-01), None
patent: 62-240673 (1987-10-01), None
patent: WO 93/17009 (1993-09-01), None
patent: WO 96/10024 (1996-04-01), None
patent: 99/5138 (1999-02-01), None
patent: 00/43385 (2000-07-01), None
patent: WO 02/088112 (2002-11-01), None
patent: WO 2004/037812 (2004-05-01), None
patent: WO 2005/095389 (2005-10-01), None
U.S. Appl. No. 11/404,078, filed Apr. 14, 2006, Yaguchi, et al.
Bonny L. Johnson, et al., “Hexamethylmelamine in Alkylating Agent-Resistant Ovarian Carcinoma”, Cancer, vol. 42, Nov. 1978, pp. 2157-2161.
Toshiyuki Matsuno, et al., “Synthesis and Aromatase-Inhibitory Activity of Imidazolyl-1,3,5-triazine Derivatives”, Chem. Pharm. Bull., vol. 45, No. 2, Feb. 1997, pp. 291-296.
Shin-Ichi Yaguchi, et al., The 64thAnnual Meeting Abstract of the Japanese Cancer Association, W-018, and PA2-0729-PA20732, Sep. 2005 (with English abstracts).
Shin-ichi Yaguchi, et al., The 96thAnnual Meeting Abstract of American Association for Cancer Research, 1691, C65 and C239, Nov. 2005, 6 pages.
Shin-ichi Yaguchi, et al., “Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor”, Journal of the National Cancer Institute, vol. 98, No. 8, Apr. 19, 2006, pp. 545-556.
Shin-ichi Yaguchi, et al., “In Vitro Cytotoxicity of Imidazolyt-1,3,5-triazine Derivatives”, Biol. Pharm. Bull., vol. 20, No. 6, Jun. 1997, pp. 698-700.
Yuichi Iino, et al., “Antitumor Effects of SEF19, a New Nonsteroidal Aromatase Inhibitor, on 7,12-Dimethylbenz [a] anthracene-Induced Mammary Tumors in Rats”, Anticancer Research, vol. 18, 1998, pp. 171-176.
Takao Yamori, et al., “A novel Phosphatidylinositol 3-kinase Inhibitor, ZSTK474, and its Preclinical Activity”, the 10thInternational Symposium on Cancer Chemotherapy, Jan. 2006, 2 pages.
U.S. Appl. No. 10/594,994, filed Sep. 29, 2006, Kawashima, et al.
Chem. Pharm. Bull vol. 48, No. 11, pp. 1778-1781, 2000.
Toshiyuki Matsuno, et al., Chem. Pharm. Bull., vol. 48, No. 11, pp. 1778-1781, 2000.
Cecil Textbook of Medicine, Edited by Bennet, J.C., and Plum F., 20thEdition, vol. 1, pp. 1004-1010 (1996).
Connor, et al., Fundamental and Applied Toxicology, vol. 30(1):93-101 (1996).
Coley, et al. Anticancer Research 16(4A); pp. 1851-1855 (1996).
Kawashima Seiichiro
Matsuno Toshiyuki
Sasahara Hiroya
Watanabe Tetsuo
Yaguchi Shinichi
Balasubramanian Venkataraman
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Zenyaku Kogyo Kabushiki Kaisha
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