Heterocyclic chromenes

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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544234, 544345, 546 89, C07D49112

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active

055279112

ABSTRACT:
The invention relates to photochromic compounds of general formula: ##STR1## in which R.sup.a, R.sup.b and R.sup.c denote hydrogen; alkyl; aryl; OR, SR, COR or COOR, in which R denotes hydrogen, alkyl or aryl, amino of formula NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2 denote hydrogen, alkyl, cycloalkyl, aryl, R.sub.1 and R.sub.2 being capable of forming with the nitrogen atom, a heterocycle containing 4 to 7 members and capable of containing, in addition, one or more heteroatoms chosen from nitrogen, oxygen, sulfur, a halogen atom; a mono- or polyhaloalkyl group; an NO.sub.2, CN or SCN group; n and m denote integers from 1 to 5 depending on the number of substitutions on the nucleus and p may be equal to 1 or 2 depending on the number of substitutions on the nucleus; H is an aromatic heterocycle having 4 to 7 members containing one or more heteroatoms chosen from nitrogen, oxygen, sulfur, these heterocyclic nuclei being capable of being substituted by one or more alkyl, alkoxy, amino, aryl or aralkyl groups or condensed with an aromatic nucleus, and to their use in ophthalmic optics.

REFERENCES:
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patent: 5266447 (1993-11-01), Takahashi et al.
patent: 5349065 (1994-09-01), Tanaka et al.
Azerad, Robert, "No. 490.--Isomerisation acide des tocoquinones. II.--Synthese de dichromannes apparentes aux tocoquinones," Bulletin de la Societe Chimique de France, 8:2728-2735, 1967, published in Europe.
Tanaka et al., "Naphthopyrans and analogs as photochromic agents and their preparation," Chemical Abstracts, vol. 113, No. 9, Aug. 27, 1990, Abstract No. 78167f, published in USA.
Ohazaki et al., "Preparation of Chromene Compounds as Photochromic Substances," Chemical Abstracts, 115(19), Abstract No. 207975k, p. 1021.

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