Heterocyclic chemicals, their preparation and use

Details Heterocyclic chemicals, their preparation and use Heterocyclic chemicals, their preparation and use

1980-12-22

1983-04-05

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548192, C07D27738, A61K 31425

Patent

active

043791565

ABSTRACT:
Compounds of formula (III): ##STR1## wherein R.sup.5 is a single substituent in position 2 or 3 of the phenyl ring and when in the 2-position R.sup.5 is a chlorine atom, a methyl group or a nitro group; and R.sup.6 is a hydrogen atom or a CO.CH.sub.3 group may be prepared by methods analogous to those known in the art, for example, by reaction of the corresponding nitrothiazolyl benzamide with the corresponding halo(di)acetamide. The compounds of formula (III) have schistosomicidal activity and may be administered either as the compound alone or as a pharmaceutical formulation.

REFERENCES:
patent: 3499907 (1970-03-01), Islip
patent: 3523122 (1970-08-01), Capps
patent: 3660417 (1972-05-01), Islip
patent: 3671650 (1972-06-01), Islip
patent: 3950351 (1976-04-01), Rossignol et al.

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