Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-08-07
2000-11-21
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514314, 514340, 514369, 514423, A61K 31425, A61K 3147, A61K 3144, A61K 3140
Patent
active
061503878
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/FR97/00209, filed Feb. 3, 1997.
Today, drug dependence, pharmacomania and, more generally, the abuse of legal or banned substances is a major problem in the world, and products enabling these behaviour patterns to be decreased or abolished have become necessary.
Compounds enabling drug abuse or the abuse of substances giving rise to pharmacomania or to overuse, that is to say compounds which decrease or abolish the taking of these products, have now been found, and this forms the subject of the present application. Among these drugs and substances giving rise to pharmacomania or to overuse, there may be mentioned nicotine, benzodiazepines, caffeine, narcotics such as amphetamines, cocaine, cannabinoids, morphine and derivatives and opioids, hallucinogens such as LSD, ecstasy, mescaline and psylocibin and, in general, all compounds whose abuse poses a public health problem.
The present invention relates to the use of derivatives of formula: ##STR1## their racemates and enantiomers when they contain one or more asymmetric centres and their salts, for the treatment of drug abuse or the abuse of substances giving rise to pharmacomania or to overuse, with the exception of alcohol abuse.
The present invention also relates to the use of these compounds for the manufacture of a medicament intended for the treatment of drug abuse or the abuse of substances giving rise to pharmacomania or to overuse, with the exception of alcohol abuse.
In the formula (I), a sulphur atom, R.sub.1 represents a pyridyl radical optionally substituted with one or more alkyl radicals, a furyl radical optionally substituted with one or more alkyl radicals, a thienyl radical optionally substituted with one or more alkyl radicals, a quinolyl radical optionally substituted with one or more alkyl radicals, a naphthyl radical optionally substituted with one or more alkyl radicals, an indolyl radical optionally substituted with one or more alkyl radicals or a phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, hydroxyl, nitro, amino, monoalkylamino, dialkylamino, alkoxycarbonyl, --CO--NR.sub.7 R.sub.8 --NH--CO--CH.sub.3, trifluoromethyl and trifluoromethoxy radicals and R.sub.5 represents a hydrogen atom, R.sub.5 represents a phenyl radical, a hydrogen atom, cycloalkylalkyloxycarbonyl or --CONR.sub.9 R.sub.10 radical or a phenyl radical optionally substituted with one or more substituents chosen from alkyl, alkoxy and hydroxyl radicals, substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals), naphthyl, indolyl or quinolyl radical or a phenylamino radical in which the phenyl ring is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, alkylthio, trifluoromethyl, carboxyl, alkoxycarbonyl, hydroxyl, nitro, amino, acyl, cyano, sulphamoyl, carbamoyl, hydroxyiminoalkyl, alkoxyiminoalkyl, hydroxyaminocarbonyl, alkoxyaminocarbonyl, 5-tetrazolyl, 5-tetrazolylalkyl, trifluoromethylsulphonamido, alkylsulphinyl, mono- or polyhydroxyalkyl, sulpho, -alk-O--CO-alk, -alk-COOX, -alk-O-alk, -alk'-COOX, --O -alk-COOX, --CH.dbd.CH--COOX and --CO--COOX radicals, -alk-SO.sub.3 H radicals in salt form and --CH.dbd.CH-alk', --C(.dbd.NOH)--COOX, --S-alk-COOX, --O--CH.sub.2 -alk'-COOX, --CX.dbd.N--O-alk-COOX, -alk-N(OH)--CO-alk and 2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl radicals, phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, are attached, form a saturated or unsaturated, mono- or polycyclic heterocycle containing 4 to 9 carbon atoms and one or more hetero atoms (O, N) and optionally substituted with one or more alkyl radicals, or phenylalkyl radical or a phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, radical or a p
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Bohme Andrees
Dubroeucq Marie-Christine
Fratta Walter
Guyon Claude
Imperato Assunta
Jarvis William R. A.
Rhone-Poulenc Rorer S.A.
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