Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-05
1997-10-21
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514309, 514248, 514259, 544220, 544239, 544287, 546141, A61K 3153, C07D25100
Patent
active
056796773
DESCRIPTION:
BRIEF SUMMARY
The invention relates to compounds of the general formula (I) ##STR2## in which a) substituted C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl-C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl radical or for a heterocyclic radical, following meaning: C.sub.6 - lower alkoxy radicals, C.sub.1 - to C.sub.6 - lower alkylthio radicals, halogen atoms, nitro groups, hydroxyl groups, trifluoromethyl radicals, cyano radicals, sulpho radicals, C.sub.1 - to C.sub.6 - lower alkylsulphonyl groups, carboxylic acid groups, C.sub.1 - to C.sub.6 - lower alkoxycarbonyl radicals, C.sub.1 - to C.sub.6 - lower alkoxycarbonyloxy radicals, acetamido radicals, benzamido radicals or the group --N(R.sup.6)R.sup.7, for a C.sub.1 - to C.sub.6 - lower alkyl radical, for a substituted C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl-C.sub.1 - to C.sub.6 - lower alkyl radical or for an aryl radical, or a C.sub.1 - to C.sub.6 - lower alkyl radical, alkyl radical, for a substituted C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl-C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl radical or for a heterocyclic radical, following meaning: C.sub.6 - lower alkoxy radicals, C.sub.1 - to C.sub.6 - lower alkylthio radicals, halogen atoms, nitro groups, hydroxyl groups, trifluoromethyl radicals, cyano radicals, sulpho radicals, C.sub.1 - to C.sub.6 - lower alkylsulphonyl groups, carboxylic acid groups, C.sub.1 - to C.sub.6 - lower alkoxycarbonyl radicals, C.sub.1 - to C.sub.6 - lower alkoxycarbonyloxy radicals, acetamido radicals, benzamido radicals or the group --N(R.sup.6)R.sup.7, and C.sub.3 - to C.sub.6 - lower alkyl radical, a phenyl radical or a benzyl radical, at least one radical R.sup.2 or R.sup.3 is different from a hydrogen atom or a halogen atom, radical, for an aryl-C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl radical or for a heterocyclic radical, mentioned under a), alkyl radical, and substituted C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl-C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl radical or for a heterocyclic radical, mentioned under a), radical, foe an aryl-C.sub.1 - to C.sub.6 - lower alkyl radical or for an aryl radical, and substituted C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl-C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl radical or for a heterocyclic radical, mentioned under a), or for a radical of the general formula (II) oxygen atom and substituted C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl-C.sub.1 - to C.sub.6 - lower alkyl radical or for an aryl radical, and radical, for an aryl radical or for a heterocyclic radical, mentioned under a), alkyl radical, for a substituted C.sub.1 - to C.sub.6 - lower alkyl radical, for an aryl-C.sub.1 - to C.sub.6 - lower alkyl radical or for an aryl radical, and atoms, R.sup.1 is different from an unsubstituted phenyl radical,
Compounds of the general formula (I) are to be emphasized in which X denotes the group CR.sup.4 and Y denotes the group CR.sup.5 and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, m and n have the meanings mentioned under Claim 1a.
Compounds of the general formula (I) are further to be emphasized in which X and Y denote a nitrogen atom and R.sup.1, R.sup.2, R.sup.3 m and n have the meanings mentioned under Claim 1b.
Compounds of the general formula (I) are further to be emphasized in which X denotes a nitrogen atom and Y denotes the group CR.sup.5 and R.sup.1, R.sup.2, R.sup.3, R.sup.5, m and n have the meanings mentioned under Claim 1c.
Compounds of the general formula (I) are further to be emphasized in which X denotes a nitrogen atom and Y denotes the group CR.sup.5 and R.sup.1, R.sup.2, R.sup.3, R.sup.5, m and n have the meanings mentioned under Claim 1d.
Compounds of the general formula (I) are further to be emphasized in which Y denotes a nitrogen atom and X denotes the group CR.sup.4 and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.8, m and n have the meanings mentioned under Claim 1e.
For the various substituents or radicals mentioned in connection with the pr
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Klauser Rainer
Pill Thomas
Raake Wolfram
Zeiller Peter
Luitpold Pharma GmbH
McKane Joseph
Myers, Jr. Richard S.
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