Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-28
1998-12-01
Clardy, S. Mark
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514443, 514444, 514469, 514255, 514256, 514258, 514365, 514372, 514373, 514374, 514375, 514415, 544253, 548152, 548217, 548237, 549 49, 549 58, 549491, 549492, A61K 3138, A61K 31425, C07D30702, C07D27760
Patent
active
058439722
ABSTRACT:
The present invention relates to certain compounds of the formula (I) the racemic-enantiomeric mixtures and optical isomers of said compounds and the pharmaceutically acceptable salts or prodrugs thereof, depicted below, which are .beta.-adrenergic receptor agonists and accordingly have utility as, inter alia, hypoglycemic and antiobesity agents. More specifically, the compounds of the instant invention are selective agonists of .beta..sub.3 -adrenergic receptor. The invention also relates to methods of use for the compounds and to pharmaceutical compositions containing them. The compounds of the present invention also possess utility for increasing lean meat deposition and/or improving the lean meat to fat ratio in animals, e.g., ungulate animals, companion animals and poultry. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Y and Z are as defined in the specification.
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Dow Robert L.
Wright Stephen W.
Benson Gregg C.
Clardy S. Mark
Pfizer Inc.
Qazi Sabiha N.
Richardson Peter C.
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