Heterocyclic arylsulfonamidobenzylic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S561000

Reexamination Certificate

active

07112606

ABSTRACT:
Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.

REFERENCES:
patent: 3281466 (1966-10-01), Stecker et al.
patent: 3495177 (1968-10-01), Jones et al.
patent: 4093738 (1978-06-01), Hubele
patent: 4093742 (1978-06-01), Neustadt
patent: 4107303 (1978-08-01), Aldrich et al.
patent: 4166123 (1979-08-01), Harrison et al.
patent: 4187232 (1980-02-01), Evans et al.
patent: 4199597 (1980-04-01), Neustadt et al.
patent: 4204002 (1980-05-01), Hubele
patent: 4218448 (1980-08-01), Aldrich et al.
patent: 4230635 (1980-10-01), Neustadt
patent: 4235928 (1980-11-01), Eicken et al.
patent: 4240979 (1980-12-01), Baumann et al.
patent: 4251534 (1981-02-01), Aldrich et al.
patent: 4251659 (1981-02-01), Aldrich et al.
patent: 4267193 (1981-05-01), Neustadt et al.
patent: 4501746 (1985-02-01), Krumkalns
patent: 5310760 (1994-05-01), Washburn et al.
patent: 5439915 (1995-08-01), Commons et al.
patent: 5861532 (1999-01-01), Brown et al.
patent: 5883106 (1999-03-01), Stevens et al.
patent: 5952368 (1999-09-01), Kertesz et al.
patent: 6030991 (2000-02-01), Chan et al.
patent: 6090853 (2000-07-01), Wetterich et al.
patent: 6156766 (2000-12-01), Arita et al.
patent: 6162830 (2000-12-01), Connor et al.
patent: 6174905 (2001-01-01), Suzuki et al.
patent: 6191170 (2001-02-01), Medina
patent: 6197798 (2001-03-01), Fink et al.
patent: 6201013 (2001-03-01), Bloom et al.
patent: 6211241 (2001-04-01), Islam et al.
patent: 6211242 (2001-04-01), Setoi et al.
patent: 6214880 (2001-04-01), Houze
patent: 6242493 (2001-06-01), Gareau et al.
patent: 6316503 (2001-11-01), Li et al.
patent: 872311 (1979-05-01), None
patent: 25 15 113 (1975-10-01), None
patent: 26 25 227 (1976-12-01), None
patent: 26 25 242 (1976-12-01), None
patent: 44 37 999 (1996-05-01), None
patent: 44 38 020 (1996-05-01), None
patent: 0 012 428 (1980-06-01), None
patent: 0 013 360 (1980-07-01), None
patent: 0 019 745 (1980-12-01), None
patent: 0 023 669 (1981-02-01), None
patent: 0 193 249 (1986-09-01), None
patent: 0 919 542 (1999-06-01), None
patent: 1 507 340 (1978-04-01), None
patent: 6323822 (1988-02-01), None
patent: 0756392 (1995-07-01), None
patent: 07118215 (1995-07-01), None
patent: WO 94/21611 (1994-09-01), None
patent: WO 97/31637 (1997-09-01), None
patent: WO 97/35838 (1997-10-01), None
patent: WO 99/06382 (1999-02-01), None
patent: WO 99/40064 (1999-08-01), None
patent: WO 99/44987 (1999-09-01), None
patent: WO 00/26186 (2000-05-01), None
patent: WO 00/46203 (2000-08-01), None
patent: WO 00/54759 (2000-09-01), None
patent: WO 01/60818 (2001-08-01), None
Grefhorst et al., Am J Physiol Endocrinol Metab. Jun. 7, 2005: [Epub ahead of print], Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice.
Stein et al., Biochimica et Biophysica Acta 1686 (2004), 24-29.
Lund et al., Arterioscler Thromb Vasc Biol., Jul. 2003, 1169-1177.
Chisholm et al., Journal of Lipid Research, vol. 44, 2003, pp. 2039-2048.
Abramovitch, R., et al., “Mechanism of direct side-chain acylamination and aminoarylation of 2- and 4-picoline 1-oxides” J. Chem Soc. 11:561-2, Database CAS Online, Chem Abstr., Accession No. 1981:568016 (1981).
Beckwith, A., et al., “Tandem radical translocation and homolytic aromatic substitution: a convenient and efficient route to oxindoles” J. Chem. Commun. pp. 977-978 (1995).
Chkanikov, N. et al., “Hexafluoroacetone and methyl trifluoropyruvate as precursors of modified esters of n-acyl-n-phenyl-α-amino acids” Bulletin of the Russian Academy of Sciences 41(8) Part 2:1415-1424, 1992.
Database CAS Online on STN, Chem. Abstr., Accession No. 1998:1455, WO 9746524 A1 (F. Hoffman-La Roche A.G., Switz.) Dec. 11, 1997, abstract.
Gilbert et al., “Perhalo ketones-(VI) aromatic amino dervs. of the penhaloacetones” Database 'Online! accession No. 16091f; [Russian Abstract], 1992.
Le Blanc, S., et al., “New access to spiranc β-lactams” Tetrahedron Lett. 33(15):1993-1996 (1992).
Masazumi I. et al., “Photochemical synthesis of spiro-β-lactams” J. Chem. Soc. Chem. Commun. pp. 758-759 (1984).
Masazumi, I., et al., “Photochemistry of 2-(N-acyl-N-alkylamino)cyclohex-2-enones: formation of spiro-β-lactams” Chem. Pharm. Bull. 34(12):4997-5004 (1986).
Miryan et al., “Derivatives of pyridinecarboxylic acids. Synthesis and antiexudative effect of fluorinated derivatives of nicotinamide and isonicotinamide” Database Chemabs 'Online! Chemical Abstract Service, accession No. 86:139798, 11(1):70-2 (1997) [Russian Abstract].
Polishchuck, V. et al., “Electron paramagnetic resonance spectra of 2-arylpolyfluoroisopropyl radicals” Database Chemabs 'Online! Chemical Abstract Service accession No. 91:4737, 3:659-661 (1979) [Russian Abstract].
Schwarz, M., et al., “Solid-phase synthesis of 3,5-disubstituted 2,3-dihydro-1,5-benzothiazepin-r(5H)-ones” J. Org. Chem. 64:2219-2231 (1999).
Laffitte et al., 2002 “Orphan Nuclear Receptors Find a Home in the Arterial Wall,”Current Atherosclerosis Reports,4(3):213-221.
Cao et al., 2003 “Antidiabetic Action of a Liver X Receptor Agonist Mediated by Inhibition of Hepatic Gluconeogenesis,”The Journal of Biological Chemistry,278(2):1131-1136.
Joseph et al., 2003 “Synthetic LXR Ligand Inhibits the Development of Atherosclerosis in Mice,”PNAS.99(11):7604-7609.

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