Heterocyclic analgesic compounds and methods of use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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C514S315000, C514S327000, C514S331000, C546S022000, C546S024000, C546S217000, C546S233000, C546S234000, C546S242000, C546S247000

Reexamination Certificate

active

07129228

ABSTRACT:
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-coupled receptors, and ion channels. An additional aspect of the present invention relates to the use of the novel heterocyclic compounds as analgesics.

REFERENCES:
patent: 3164600 (1965-01-01), Janssen et al.
patent: 3655675 (1972-04-01), Carabateas
patent: 3998834 (1976-12-01), Janssen et al.
patent: 4138492 (1979-02-01), Noverola et al.
patent: 4167574 (1979-09-01), Janssens
patent: 4584303 (1986-04-01), Huang et al.
patent: 4791120 (1988-12-01), Lin et al.
patent: 4791121 (1988-12-01), Kudzma et al.
patent: 4831192 (1989-05-01), Lin et al.
patent: 4859685 (1989-08-01), Jerussi et al.
patent: 4863918 (1989-09-01), Gala et al.
patent: 4871749 (1989-10-01), Lin et al.
patent: 4900738 (1990-02-01), Bagley et al.
patent: 4912109 (1990-03-01), Bagley et al.
patent: 4916142 (1990-04-01), Bagley et al.
patent: 4921864 (1990-05-01), Kudzma et al.
patent: 4939161 (1990-07-01), Lalinde et al.
patent: 4954506 (1990-09-01), Bagley et al.
patent: 4957929 (1990-09-01), Kudzma et al.
patent: 4994471 (1991-02-01), Lalinde et al.
patent: 5013742 (1991-05-01), Kudzma et al.
patent: 5015781 (1991-05-01), Robin et al.
patent: 5198449 (1993-03-01), Shanklin, Jr.
patent: 5290796 (1994-03-01), DeHaven-Hudkins et al.
patent: 5817678 (1998-10-01), Kim et al.
patent: 6451842 (2002-09-01), Shiota et al.
patent: 6635661 (2003-10-01), Cuny et al.
patent: 6645980 (2003-11-01), Cuny et al.
patent: 6677332 (2004-01-01), Cuny et al.
patent: 2003/0069418 (2003-04-01), Aquila et al.
patent: 2 340 874 (1974-02-01), None
patent: 0 160 422 (1985-11-01), None
patent: 0 256 798 (1988-02-01), None
patent: 0 261 842 (1988-03-01), None
patent: 0 277 794 (1988-08-01), None
patent: 0 333 427 (1989-09-01), None
patent: 0 343 900 (1989-11-01), None
patent: 394 039 (1990-10-01), None
patent: 0 396 282 (1990-11-01), None
patent: 0 466 585 (1992-01-01), None
patent: 2 338 043 (1977-08-01), None
patent: 2 729 142 (1996-07-01), None
patent: 1 382 526 (1975-02-01), None
patent: 1 382 965 (1975-02-01), None
patent: 02-138170 (1990-05-01), None
patent: 031 482 23 (1991-06-01), None
patent: 110 355 55 (1999-02-01), None
patent: WO89/04300 (1989-05-01), None
patent: WO 97/08155 (1997-03-01), None
patent: WO 97/18813 (1997-05-01), None
patent: WO 98/28275 (1998-07-01), None
patent: WO 99/24423 (1999-05-01), None
patent: WO 99/33806 (1999-07-01), None
patent: WO 00/06545 (2000-02-01), None
patent: WO 00/09491 (2000-02-01), None
patent: WO 00/023438 (2000-04-01), None
patent: WO 00/26186 (2000-05-01), None
patent: WO 00/27815 (2000-05-01), None
patent: WO 00/53596 (2000-09-01), None
patent: WO 00/71518 (2000-11-01), None
Stefan Van Den Branden et al. “Mimicking of Ergot Alkaloids and Synthetic Piperidine Druge 2.5-Substituted Piperidines Derived from Cis and Trans Ethyl 1-Benzyl-6-Cyano-3-Piperidinecarboxylate”, Tetrahedron 48 (44): 9753-9766 (1992).
Sternfeld et al.; “Synthesis and Serotonergic Activity of 3-[2-(Pyrrolidin-1-yl)ethyl] Indoles: Potent Agonist for the h5-HTIDReceptor with High Selectivity Over the h5-HTIBReceptor”, J. Med. Chem. 42: 677-690, (1999).
International Search Report made on PCT/US 00/ 14579, mailed on Nov. 29, 2000.
Harada et al.; “Development of Potent Seratonin-3 (5-HT3) Receptor Antagonists. I. Structure-Activity Relationships of 2-Alkoxy-4-amino-5-chlorobenzamide Derivatives”, Chem. Pharm. Bull.43 (8): 1364-1378 (1995).
Muro et al.; “115499q Preparation of (pyridycarbomoyl) Piperidine Derivatives as Cardiovascular Agents and Antihypertensives”, Chemical Abstracts, 107(13): 6001, (Sep. 28, 1987).
Welstead et al., Aminoalkylindoles With Central Nervous System Activity, P. D., 10: 1015-1021, (Nov. 1967).
Zheng et al.; “Design and Synthesis of Antiplatelet Nipecotamides with a Dual Mechanism of Action”, Medicinal Chemistry Research 7(4): 219-227, (1997).
International Search Report Completed on Jul. 12, 2002 and Mailed on Aug. 20, 2002.
Golovin et al.; “Synthesis of Substituted cis-3-aminoethyl-4-Hydroxypiperidines and Their acyl Derivatives”, Khim, Geterotsiki. Soedin, 10: 1363-8,(1978) CAS print out.
Carelli et al.; “Substituted N-(Pyridylmethyl) Anilides with Local Anesthetic Action”, Farmaco Ed. Sci. 16: 375-386, (1961); Chemical Abstracts Accession No. 1962: 31337, Document No. 56: 31337.
Kakefuda et al., An Efficient Synthesis of (+)-6,7-dimethyoxy-1-oxo-2-(3-piperidyl)-1,2,3,4-tetrahydroisoqunioline, Synthetic Communications, vol. 31, No. 3, pp. 401-408, 2001.
CAPLUS printout of COSTAKIS et al., Synthesis and Preliminary Pharmacological Study of some .alpha.-phenylalkylamines, Annales Pharmaceutiques Francaise, vol. 36, No. 7-8, pp. 349-360, 1978.
CAPLUS printout of PITRE et al., 1-Amino-1,3-diphenylethane Derivatives, Farmaco Edizione Scientifica, vol. 17, pp. 130-140, 1962.

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