Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-10-06
1995-07-25
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142282, 5142302, 5142332, 514250, 514254, 546 95, 544 60, 544101, 544115, 544126, 544344, A61K 3150, A61K 31495, C07D51312, C07D47112
Patent
active
054362407
ABSTRACT:
Tricyclic nitrogen containing compounds, having central nervous system activity of the following structural formula: ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen, C.sub.1-6 alkyl, alkenyl, or alkynyl, C.sub.3-10 cycloalkyl, or R.sub.1 and R.sub.2 are joined to form a C.sub.3-7 cyclic amine which can contain additional heteroatoms; X is hydrogen, C.sub.1-6 alkyl, halogen, hydroxy, alkoxy, cyano, carboxamide, carboxyl, or carboalkoxyl; A is SO.sub.2, N, CH, CH.sub.2, CHCH.sub.3, C=O, C=S, C-SCH.sub.3, C=NH, C-NH.sub.2, C-NHCH.sub.3, CNHCOOCH.sub.3, or C-NHCN. B is CH.sub.2, CH, C=O, N, NH or N-CH.sub.3 ; n is 0 or 1; and D is CH, CH.sub.2, C=O, 0, N, NH or N-CH.sub.3. These new compounds are suitable for treating schizophrenia, Parkinson's disease, anxiety, depression or as compounds for lowering blood pressure in animal or human hosts.
REFERENCES:
patent: 3200123 (1965-08-01), Richardson et al.
patent: 4015005 (1977-03-01), Hardtmann
patent: 4110339 (1978-08-01), Bach et al.
patent: 4550114 (1985-10-01), White
patent: 4808619 (1989-02-01), Evans et al.
patent: 4952584 (1990-08-01), Thompson et al.
patent: 5021438 (1991-06-01), Junge et al.
patent: 5112830 (1992-05-01), Shutske et al.
Evans, D. D. et al., "1,3,4,5-Tetrahydrobenz[cd]indoles and Related Compounds. Part V. Some Reactions of 1,2,4,5-Tetrahydropyrrolo[3,2,1-ij]quinolin-6-one," J. S. C. Perkin I, 285-288 (1974).
K. Sempuku, "Tetracyclic Compounds," Chemical Abstract 95:62240y, (1981).
Heier Richard F.
Moon Malcolm W.
Morris Jeanette K.
Corneglio Donald
Grumbling Matthew V.
Shah Mukund J.
The Upjohn Company
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