Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-04-08
1996-05-28
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
546 24, 546193, 5462821, 5462824, 5462844, 5462847, 5462834, 546 23, 5462727, 546174, 546175, 546256, 5462684, 5462714, 5462717, 5462697, 5462707, 5462704, 5462741, 5462744, 546292, 546291, 5462747, 5462771, 5462787, 5462784, 5462774, 5462777, 5462781, 5462791, 5462814, 5142368, 514247, 514346, 514349, 544224, 544360, 544362, C07D23700, C07D21172, C07D40100, C07D21514
Patent
active
055211798
ABSTRACT:
The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.
REFERENCES:
patent: 4474778 (1984-10-01), Gordon et al.
patent: 4910190 (1990-03-01), Bergeson et al.
B. Imperali & R. H. Abeles "Inhibition of Serine Preteases by Peptidyl Fluoromethyl Ketones" Biochemistry (1986), 25, 3760-3767.
C. P. Sommerhoff et al "Inhibition of Human Neutrophil Elastase by ICI 200,355" European Journal of Pharmacology, (1991), 193, 153-158.
Bernstein Peter R.
Shaw Andrew
Thomas Royston M.
Warner Peter
Wolanin Donald J.
Alexander Michael D.
Compton Raymond
Harris Robert J.
Ivy C. Warren
Newtson Ruth H.
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