Heterocyclic amide derivatives as inhibitors of glycogen...

Details Heterocyclic amide derivatives as inhibitors of glycogen... Heterocyclic amide derivatives as inhibitors of glycogen...

2007-10-02

2007-10-02

Anderson, Rebecca (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S122000

Reexamination Certificate

active

11463144

ABSTRACT:
Heterocyclic amides of formula (1)wherein:X is N or CH;R4and R5together are either —S—C(R6)═C(R7)— or —C(R7)═C(R6)—S—;R6and R7are independently selected from, for example hydrogen, halo and C1-4alkyl;A is phenylene or heteroarylene;n is 0, 1 or 2;R1is selected from for example halo, nitro, cyano, hydroxy, carboxy;R2is hydrogen, hydroxy or carboxy;R3is selected from for example hydrogen, hydroxy, aryl, heterocyclyl and C1-4alkyl(optionally substituted by 1 or 2 R8groups);R8is selected from for example hydroxy, —COCOOR9, —C(O)N(R9)(R10), —NHC(O)R9, (R9)(R10)N— and —COOR9;R9and R10are selected from for example hydrogen, hydroxy, C1-4alkyl (optionally substituted by 1 or 2 R13);R13is selected from hydroxy, halo, trihalomethyl and C1-4alkoxy;or a pharmaceutically acceptable salt or pro-drug thereof, possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.

REFERENCES:
Buckle et al. J. Med. Chem. 1975, 18(7), 726-32.

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