Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-10-31
2006-10-31
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S312000, C546S122000, C546S156000
Reexamination Certificate
active
07129249
ABSTRACT:
Heterocyclic amides of formula (1)wherein:X is N or CH;R4and R5together are either —S—C(R6)═C(R7)— or —C(R7)═C(R6)—S—;R6and R7are independently selected from, for example hydrogen, halo and C1-4alkyl;A is phenylene or heteroarylene;n is 0, 1 or 2;R1is selected from for example halo, nitro, cyano, hydroxy, carboxy;R2is hydrogen, hydroxy or carboxy;R3is selected from for example hydrogen, hydroxy, aryl, heterocyclyl and C1-4alkyl(optionally substituted by 1 or 2 R8groups);R8is selected from for example hydroxy, —COCOOR9, —C(O)N(R9)(R10), —NHC(O)R9, (R9)(R10)N— and —COOR9;R9and R10are selected from for example hydrogen, hydroxy, C1-4alkyl (optionally substituted by 1 or 2 R13);R13is selected from hydroxy, halo, trihalomethyl and C1-4alkoxy;or a pharmaceutically acceptable salt or pro-drug thereof; possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.
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Birch Alan Martin
Morley Andrew David
Stocker Andrew
Whittamore Paul Robert Owen
AstraZeneca AB
Nolan Jason M.
Saeed Kamal A.
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