Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-12-21
2009-06-23
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S254060, C540S575000, C544S355000, C544S357000, C544S362000, C544S363000, C544S364000, C544S370000, C544S373000, C544S376000, C546S126000, C546S198000, C546S199000, C546S202000
Reexamination Certificate
active
07550469
ABSTRACT:
The invention relates to heterocyclic substituted amide derivatives that display selective binding to dopamine D3receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D3receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine D3receptors.
REFERENCES:
patent: 7186724 (2007-03-01), Hendrix et al.
Bordeau Kenneth
Gill Harpal
Hemmerle Horst
Hendrix James A
Jackson Sharon Anne
Aventis Pharmaceuticals Inc.
Bernhardt Emily
Kurys Barbara E.
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