Heterocyclic aldose reductase inhibitors and methods of using th

Details Heterocyclic aldose reductase inhibitors and methods of using th Heterocyclic aldose reductase inhibitors and methods of using th

1985-05-14

1988-07-05

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 52, C07D27916, A61K 3154

Patent

active

047555092

ABSTRACT:
The invention relates to new compounds of the formula: ##STR1## Aldose reductase inhibitors. Treatment of certain complications of diabetes.

REFERENCES:
patent: 3923709 (1975-12-01), Worley
patent: 4512990 (1985-04-01), Nelson et al.
patent: 4584300 (1986-04-01), Iwao et al.
Shridhar et al., Chemical Abstracts, 101, 55016u (1984).
Lipinski and Hutson, "Aldose Reductase Inhibitors as a New Approach to the Treatment of Diabetic Complications", (Sep. 11, 1984), Annual Reports in Medicinal Chemistry, 19 196.
Kador, Kinoshita and Sharpless, "Aldose Reductase Inhibitors: A Potential New Class of Agents for the Pharmacological Control of Certain Diabetic Complications", (Jul. 1985), Journal of Medicinal Chemistry, 28 841.
Kador, Robison and Kinoshita, "The Pharmacology of Aldose Reductase Inhibitors", (1985), Ann. Rev. Pharmacol. Toxicol., 25, 691.

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