Heterocyclic acetylenic amines having central nervous system act

Details Heterocyclic acetylenic amines having central nervous system act Heterocyclic acetylenic amines having central nervous system act

1992-07-30

1993-07-06

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548531, 548538, 548546, 548566, 548569, 546208, C07D20709, C07D40106, C07D40306, A61K 3140

Patent

active

052255670

ABSTRACT:
Heterocyclic acetylenic amine compounds having the following structural formula ##STR1## where X is ##STR2## having cholinergic agonist or antagonist activity useful in the treatment of mental disorders, extrapyramidal motor disorders, disorders of the parasympathetic nervous system and glaucoma or as analgesics for the treatment of pain. Typical central nervous system disorders for which the subject compounds can be used include cognitive disorders of all ages, including senile dementia, Alzheimer's disease and other related disorders. The compounds are particularly developed to improve mental performance when a mental deficiency is diagnosed.

REFERENCES:
patent: 2867620 (1959-01-01), Biel
patent: 2937185 (1960-05-01), Biel
patent: 3334115 (1967-08-01), Arnold et al.
patent: 3354178 (1967-11-01), Dickinson
patent: 3925411 (1975-12-01), Dahlbom et al.
patent: 3959311 (1976-05-01), Dahlbom et al.
patent: 5001142 (1991-03-01), Trybulski et al.
B. Ringdahl, "5-Methyl-2-pyrrolidone Analogues of Oxotremorine as Selective Muscarinic Agonists," Journal of Medicinal Chemistry, 31, pp. 683-688 (1988).
B. M. Nilsson, et al., "Derivatives of the Muscarinic Agent N-Methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide," Journal of Medicinal Chemistry, 31, pp. 577-582 (1988).
Chemical Abstracts, vol. 62, entry 2155(b) (1965).

Affiliated with

Also associated with

Rating

Heterocyclic acetylenic amines having central nervous system act does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic acetylenic amines having central nervous system act, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic acetylenic amines having central nervous system act will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1691144