Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-07-19
2005-07-19
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C546S153000, C544S105000, C544S128000, C544S363000, C514S312000, C514S235200, C514S253070
Reexamination Certificate
active
06919335
ABSTRACT:
Compounds of the formulawherein X1is C(O), —S(O)—, or —S(O)2—;X2is CR3or N; X3is —NH—, —O—, or —S—;X4is CR4or N; X5is CR5or N; and X6is CR6or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH-associated disorders.
REFERENCES:
patent: 3495009 (1970-02-01), Tronche et al.
patent: 4686234 (1987-08-01), Nelson et al.
patent: 4725622 (1988-02-01), Nelson et al.
patent: 4727069 (1988-02-01), Nelson et al.
patent: 4753935 (1988-06-01), Nelson et al.
patent: 4786637 (1988-11-01), Allison et al.
patent: 4808592 (1989-02-01), Nelson et al.
patent: 4861776 (1989-08-01), Nelson et al.
patent: 4868153 (1989-09-01), Allison et al.
patent: 4948793 (1990-08-01), Allison et al.
patent: 4952579 (1990-08-01), Nelson et al.
patent: 4959387 (1990-09-01), Nelson et al.
patent: 4992467 (1991-02-01), Allison et al.
patent: 5247083 (1993-09-01), Knox et al.
patent: 5380879 (1995-01-01), Sjogren
patent: 5444072 (1995-08-01), Patterson et al.
patent: 5665583 (1997-09-01), Collart et al.
patent: 5807876 (1998-09-01), Armistead et al.
patent: WO94/01105 (1994-01-01), None
patent: WO94/12184 (1994-06-01), None
patent: WO97/40028 (1997-10-01), None
patent: WO98/40381 (1998-09-01), None
patent: WO 03/035066 (2003-05-01), None
CAS printout for Yu et al. Chem. Abs. 72:31563, 1970.
Papageorgiou, Enterohepatic recirculation: a powerful incentive for drug discorry in the inosine monophosphate dehydrogenas field, Mini. Rev. Med. Chem. 1:71-77, 2001.
Jackson et al., Nature, vol. 256, pp. 331-333, 1975.
Collart et al., J. Biol. Chem., vol. 263, No. 30, pp. 15769-15772, 1988.
Natsumeda et al., J. Biol. Chem. vol. 265, No. 9, pp. 5292-5295, 1990.
Chan et al., Tetrahed. Lett., vol. 39, pp. 2933-2936, 1998.
Lam et al., Tetrahed. Lett., vol. 39, pp. 2941-2944, 1988.
Kuo et al., J. Med. Chem, vol. 36, pp. 1146-1156, 1993.
Toda et al., Heterocycles, vol. 38, No. 9, pp. 2091-2097, 1994.
Kalinin et al., Tetrahedron Lett., vol. 33, No. 3, pp. 373-376, 1992.
Torii et al., Tetrahedron, vol. 49, No. 31, pp. 6773-6784, 1993.
Wang et al., J. Org. Chem., vol. 65, pp. 1889-1891, 2000.
Li et al., J. Med. Chem., vol. 37, pp. 3400-3407, 1994.
Babudri et al., J. Chem. Soc. Perkins Trans. I., pp. 1899-1903, 1984.
Hradil et al., J. Heterocyclic Chem., vol. 36, pp. 141-144, 1999.
Behrman et al., J. Chem. Research(s), pp. 164-165, 1995.
Miyaura et al., Synthetic Communications, 1981, vol. 11, No. 7, 513-519.
Ishiyama et al., J. Org. Chem., 1995, vol. 60, No. 23, 7508-7510.
Chen et al., Synthesis, 1987, 482-483.
Clay et al., Synthesis, 1993, 290-293.
Vysokov et al., Ruissian Journal of Organic Chemistry, 1993, vol. 34, No. 3, 428-433.
Carr et al., The Journal of Biological Chemistry, 1993, vol. 265, No. 36, 27286-27290.
Kalinin, Russian Chemical Reviews, 1991, vol. 60, No. 2, 339-373.
Konno et al., The Journal of Biological Chemistry, 1991, vol. 266, No. 1, 506-509.
Canelos et al., Journal Allergy Clin. Immunol., 2001, vol. 107, SIBO Abstracts, Abstract No. 593, p. S180.
Miyaura et al., J. Am. Chem. Soc., 1989, vol. 111, 314-321.
Sui et al., Eur. J. Med. Chem., 1999, vol. 34, 381-387.
Montero et al., Clinica Chemica Acts, 1995, vol. 238, 169-178.
Katritzky et al., Comprehensive Heterocyclic Chemistry, The Structure, Reactions, Synthesis and Uses of Heterocyclic Compounds, Pergamon Press, New York, First Edition, 1984.
Katritzky et al., Comprehensive Heterocyclic Chemistry II, A Review of the Literature 1982-1995, The Structure, Reactions, Synthesis, and Use of Heterocyclic Compounds, Pergamon Press, New York, 1996.
Larock, Comprehensive Organic Transformations, A Guide to Functional Group Preparations, pp. 389-439, VCH Publishers, Inc., 1989.
Hudlicky, Reductions in Organic Chemistry, Second Edition, ACS Monograph 188, pp. 91-101, American Chemical Society, Washington, DC, 1996.
Padwa, 1,3-Dipolar Cycloaddition Chemistry, vol. 2, John Wiley and Sons, New York, NY, 1984.
Padwa, 1,3-Dipolar Cycloaddition Chemistry, vol. 1, John Wiley and Sons, New York, NY, 1984.
Hudlicky, Oxidations in Organic Chemistry, ACS Monograph 186, American Chemical Society, Washington, DC, 1990.
Carey et al., Advanced Organic Chemisty, Third Edition, Part B: Reactions and Synthesis, Plenum Press, New York, NY, 1990.
Hagen et al., Pharmazie, vol. 46, 531-532, 1991.
Chemical Abstracts, vol. 122, No. 5, Jan. 30, 1995, Abstract No. 55994v.
Singh et al., J. Indian Chem. Soc., vol. 71, No. 3, 159-160, 1994.
Chemical Abstract, vol. 122, No. 5, Jan. 30, 1995, Abstract No. 55978t.
Levin et al., Bioorg. Med. Chem. Lett., vol. 4, No. 15, 1819-1824, 1994.
Chemical Abstracts, vol. 116, No. 11, Mar. 16, 1992, Abstract No. 106220a.
Dhar T. G. Murali
Gu Henry H.
Iwanowicz Edwin J.
Pitts William J.
Watterson Scott H.
Bristol-Myers Squibb Co.
Duncan Laurelee A.
O'Brien Maureen P.
Raymond Richard L.
LandOfFree
Heterocycles that are inhibitors of IMPDH enzyme does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterocycles that are inhibitors of IMPDH enzyme, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocycles that are inhibitors of IMPDH enzyme will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3419207