Heterocycles as cholecystokinin (CCK) ligands

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S266300, C544S116000, C544S119000, C544S287000

Reexamination Certificate

active

06897213

ABSTRACT:
Novel quinazolinone derivatives with good binding affinity for the CCK-A and CCK-B receptors, pharmaceutical compositions containing them and methods of using them are taught. The compounds are useful agents to suppress appetite, reduce gastric acid secretion, and the like.

REFERENCES:
patent: 3213094 (1965-10-01), Morgan
patent: 3217005 (1965-11-01), Kirchner
patent: 3322766 (1967-05-01), Schipper
patent: 3867384 (1975-02-01), Bullock et al.
patent: 4472400 (1984-09-01), Tully et al.
patent: 4547504 (1985-10-01), Fabre et al.
patent: 4826528 (1989-05-01), Mengel et al.
patent: 5084457 (1992-01-01), Fanshawe et al.
patent: 5196427 (1993-03-01), Yu et al.
patent: 5204354 (1993-04-01), Chakravarty et al.
patent: 5276038 (1994-01-01), Takasugi et al.
patent: 5278316 (1994-01-01), Horwell et al.
patent: 5354755 (1994-10-01), Takasugi et al.
patent: 158549 (1983-01-01), None
patent: 2086903 (1981-11-01), None
patent: 9426722 (1994-11-01), None
Kottka et al., Chem. Abstract 104:207299, 1986.*
Liebowitz, PubMed Abstract (J Clin Psychiatry 58 Suppl 13:5-8), 1997.*
K. Kottke, et al.,Chemical Abstracts,1982, 96:69016j.
K. Kottke, et al.,Chemical Abstracts,1983, 99:70757v.
K. Kottke, et al.,Chemical Abstracts,1983, 99:158378h.
A.K.S. Gupta, et al.,Chemical Abstracts,1989, 111:52455g.
A-M.M.E. Omar, et al.,Eur J Med Chem—Chemica Therapeutica,1981, 16:1, 77-80.
K. Kottke, et al.,Chemical Abstracts,1983, 98:107241e.
K. Kottke, et al.,Chemical Abstracts,1978, 89:24242u.
16128u,Chemical Abstracts,vol. 78, 1973.
87715d,Chemical Abstracts,vol. 70, 1969.
140064s,Chemical Abstracts,vol. 82, 1975.
105:97416n,Chemical Abstracts,vol. 105, 1986.
96:142790p,Chemical Abstracts,vol. 96, 1982.
85:123860t,Chemical Abstracts,vol. 85, 1976.
“Intracerebroventricular Injections of Chlecystokinin Octapeptide Suppress Feeding, etc.”,Regulatory Peptides,R.R. Schick, et al, 14 (1986) 277-291.
“Antinociceptive Action of Cholecystokinin Octapeptide, etc.”,Neuropharmacology,R.G. Hill, et al, vol. 26, No. 4, pp. 289-300, 1986.
“Inhibition of Synaptic Transmission in the Hippocampus, etc.”,Brain Research,Brian A. MacVicar, et al, 406 (1987) 130-135.
“Peptides, The Limbic Lobe and Schizophrenia”, Gareth W. Roberts, et al,Brain Research,288 (1983) 199-211.
“Cholecystokinin—Immunoreactive Boutons in Synaptic Contact, etc.”, S.Totterdell and A.D. Smith,Neuroscience,vol. 19, No. 1 pp. 181-192, 1986.
“Opposite Actions of CCK-8 on Amphetamine-Induced Hyperlocomotion, etc.”, F. Weiss, et al,Pharmacology Biochemistry&Behavior,vol. 30, pp. 3098,317 (1988).
“CCK-8 Modulation of Mesolimbic Dopamine: Antagonism of Amphetamine-Stimulated Behaviors”, L.H. Schneider, et al,Peptides,vol. 4,pp. 749-753, 1983.
“Gastrointenstinal Hormones and Gastric Secrection”, S.J.Konturek,Gastrointestinal Hormones,Ch.23, pp. 529-564 (1980) ed. G.B.J. Glass, Raven Press, NY.
“Role of Gastrin and Gastrin Receptors on the Growth of a Transplantable Mouse Colon Carcinoma, etc.”,Cancer Research 44,1612-1616, Apr., 1986.
“Effects of Gastrin, Proglumide, and Somatostatin on Growth of Human Colon Cancer”,Gastroenterology1988; 95: 1541-8.
“The Physiology of Cholecystokinin in Brain and Gut”, G.J. Dockray,British Medical Bulletin(1982) vol. 38, No. 3, pp. 253-258.
“The Neuroendocrine Control of Appetite, etc.”, John E. Morley,Life Sciences,vol. 27, pp. 355-368 (1980).
“Immunochemical Evidence of Cholecystokinin Tetrapeptides in Hog Brain”, Rehfeld and Gotterman,Journal of Neurochemistry,vol. 32, pp. 1339-1341.
“Cholecystokinin Octapeptide: Continuous Picomole Injections, etc.”, Della-Fera and Baile,Science,vol. 26, pp. 471-473 (1979).
“Heterogeneity of GABAergic Cells In Cat Visual Cortex”, H.Demeulemeester, et al,The Journal of Neuroscience,Mar. 1988 (8(3):988-1000.
“Hypnotics and Sedatives”, Stewart C. Harvey,The Pharmacological Basis of Therapeutics, 1985, pp. 339-371.
“Synthesis and some reactions of 3-phenyl(1H,3H)-quinazoline-2-thione-4-one”, El-Deen and El-Desuky,J.Serb.Chem.Soc.57(11)719-723 (1992).
“Synthesis and Anticonvulsant Activity of Some New 2-Substituted 3-Aryl-4(3H)-quinazolinones”, James F. Wolfe, et alJ.Med.Chem.1990, 33, pp. 161-166.
“Synthesis of the 1,2,4-Triazolo[4,3-a] quinazol in-5-ones and Related Compounds”, H.A. El-Sherief, et alBull.Chem.Soc.Jpn., 56,1227-1230 (1983).
“Synthesis and Pesticidal Activity of some Quinazol in-4(3H)-one Derivatives,” Gupta & Pandey,Pestic.Sci.26, 1989, 41-49.
“Synthesis of some novel quinazolone thiosemicarbazide and thiazoline derivatives for potential anti-microbial activity”, Omar, et al,Eur.J.Med.Chem.—Chemica Therapeutica,Jan.-Feb., 1981-16, No. 1, pp. 77-80.
94:175041,Chemical Abstracts,vol. 94, 1981.
94:132238j,Chemical Abstracts,vol. 94, 1981.
99:158378h,Chemical Abstracts,vol. 99, 1983.
111:52455g,Chemical Abstracts,vol. 111, 1989.
89(15):1294696,Chemical Abstracts,1978.
95(1):7198r,Chemical Abstracts,1980.
98(23):198151q,Chemical Abstracts,1983.
Chemical Abstracts,Reg. No. 146849-71-0.
Chemical Abstracts,Reg. No. 121828-87-3.
Chemical Abstracts,Reg. No. 121678-90-8.
Chemical Abstracts,Reg. No. 121662-01-9.
Chemical Abstracts,Reg. No. 121662-00-8.
Chemical Abstracts,Reg. No. 121661-99-2.
Chemical Abstracts,Reg. No. 121661-98-1.
Chemical Abstracts,Reg. No. 121661-97-0.
Chemical Abstracts,Reg. No. 121661-96-9.
Chemical Abstracts,Reg. No. 121661-95-8.
Chemical Abstracts,Reg. No. 121661-94-7.
Chemical Abstracts,Reg. No. 121661-93-6.
Chemical Abstracts,Reg. No. 121661-92-5.
Chemical Abstracts,Reg. No. 121661-91-4.
Chemical Abstracts,Reg. No. 121661-90-3.
Chemical Abstracts,Reg. No. 101164-48-1.
Chemical Abstracts,Reg. No. 87466-11-3.
Chemical Abstracts,Reg. No. 87466-10-2.
Chemical Abstracts,Reg. No. 87466-09-9.
Chemical Abstracts,Reg. No. 87466-08-8.
Chemical Abstracts,Reg. No. 87466-07-7.
Chemical Abstracts,Reg. No. 87466-06-6.
Chemical Abstracts,Reg. No. 86842-56-0.
Chemical Abstracts,Reg. No. 86842-47-9.
Chemical Abstracts,Reg. No. 86662-55-7.
Chemical Abstracts,Reg. No. 86513-40-8.
Chemical Abstracts,Reg. No. 86507-00-8.
Chemical Abstracts,Reg. No. 86506-99-2.
Chemical Abstracts,Reg. No. 86506-98-1.
Chemical Abstracts,Reg. No. 86506-97-0.
Chemical Abstracts,Reg. No. 86506-96-9.
Chemical Abstracts,Reg. No. 86506-95-8.
Chemical Abstracts,Reg. No. 86506-94-7.
Chemical Abstracts,Reg. No. 85784-60-7.
Chemical Abstracts,Reg. No. 85773-55-3.
Chemical Abstracts,Reg. No. 85773-54-2.
Chemical Abstracts,Reg. No. 85773-53-1.
Chemical Abstracts,Reg. No. 85773-52-0.
Chemical Abstracts,Reg. No. 85773-51-9.
Chemical Abstracts,Reg. No. 85773-50-8.
Chemical Abstracts,Reg. No. 85773-49-5.
Chemical Abstracts,Reg. No. 85773-48-4.
Chemical Abstracts,Reg. No. 85773-47-3.
Chemical Abstracts,Reg. No. 85773-46-2.
Chemical Abstracts,Reg. No. 85773-45-1.
Chemical Abstracts,Reg. No. 85773-44-0.
Chemical Abstracts,Reg. No. 85773-43-9.
Chemical Abstracts,Reg. No. 85773-42-8.
Chemical Abstracts,Reg. No. 85773-41-7.
Chemical Abstracts,Reg. No. 85773-40-6.
Chemical Abstracts,Reg. No. 85773-39-3.
Chemical Abstracts,Reg. No. 85773-38-2.
Chemical Abstracts,Reg. No. 85773-11-1.
Chemical Abstracts,Reg. No. 85773-10-0.
Chemical Abstracts,Reg. No. 85773-09-7.
Chemical Abstracts,Reg. No. 77775-32-7.
Chemical Abstracts,Reg. No. 77747-39-8.
Chemical Abstracts,Reg. No. 77747-38-7.
Chemical Abstracts,Reg. No. 77747-37-6.
Chemical Abstracts,Reg. No. 77747-36-5.
Chemical Abstracts,Reg. No. 77437-24-2.
Chemical Abstracts,Reg. No. 77437-23-1.
Chemical Abstracts,Reg. No. 77437-22-0.
Chemical Abstracts,Reg. No. 77437-21-9.
Chemical Abstracts,Reg. No. 77437-20-8.
Chemical Abstracts,Reg. No. 77437-19-5.
Chemical Abstracts,Reg. No. 77437-18-4.
Chemical Abstracts,Reg. No. 77437-17-3.
Chemical Abstracts,Reg. No. 77437-16-2.
Chemical Abstracts,Reg. No. 77437-15-1.
Chemical Abstracts,Reg. No. 77437-14-0.
Chemical Abstracts,Reg. No.

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