Heterocycles as antimicrobial agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514287, 514288, 514410, 514453, 514469, 514470, 546 64, 546 65, 546 66, 546113, 546116, 548421, 548453, 549 42, 549 50, 549298, 549305, A61K 3134, A61K 3140, C07D49304, C07D491048

Patent

active

061536458

ABSTRACT:
Methods for treating infection and related compositions, compounds of formula I as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit transfer ribonucleic acid (tRNA) synthetase and are useful as antimicrobial agents.

REFERENCES:
patent: 5686459 (1997-11-01), Diederich et al.
patent: 5726195 (1998-03-01), Hill et al.
Chow C.S., et al., "A Structural Basis for RNA-Ligand Interactions," Chem. Rev, 1977, pp. 1489-1513.
Herman, T, et al., "RNA as a Drug Target: Chemical, Modelling, and Evolutionary Tools," Current Opinion in Biotechnology, 1998, 9:66-73.
Pearson, N.D., "RNA as a Drug Target," Chemistry & Biology, 1997, 4:409-414.
A.G. Anastassiou, R.P. Cellura: "Thermal Cycloaddition to Oxonin," J. Chem. Soc. D., 1970, pp. 484-485.
Th. Wagner-Jauregg et al., "33. Neuartige Cycloadditionsreaktionen von 2- und 4-Vinylpyridin mit N-Alkyl-Maleinimiden," Helv. Chim. Acta, vol. 56, No. 1, 1973, pp. 440-449 (no translation provided).
Krysin M. Yu et al Zh.Org.Khim 1989, 25(10), p. 2094 X (English Abstract provided).
Krysin M. Yu et al Khim.Geterotsikl.Soedin 1987, 11, p. 1463 X (English Abstract provided).
Tsuge O et al "Simple Generation of Ester-Stabilized Azomethine Ylides from 2-Amino Esters and Carbonyl Compounds, Stereochemistry of Their Cycloadditions," Bull.Chem.Soc.Jpn 1987, 60(11), p. 4067-4078.
Andrist A et al "Ozonolysis of Tetrahydrophthalimides (Cyclohex-4-ene-1,2-dicarboximides): A Sterically Dependent Unsymmetrical Oxidative Cleavage Reaction," J.Chem.Soc.Perkin Trans 1 1978, 9, p. 918-923.
Prein A et al, "Site Selectivity in the Rhodium(II)-Catalyzed Reaction of -Diazoimides, Ligand and Substituent Effects," Tetrahedron 1997, 53(23), p. 7777-7793.
Tsuge O et al, "Stable Configuration of Ester-Stabilized Azomethine Ylides, Stabilization of Anti-Form by 1,5-Dipolar Interaction and of syn-Form by Hydrogen Bonding," Chem Lett 1986, (8), p. 1271-1274.
Fannes C et al, "Cycloaddition of Olefinic Compounds to2H-1,4-Oxazin-2-ones: Synthesis of 2-Oxa-5-Azabi-cyclo[2,2,2]oct-5-en-3-ones," Synthesis 1992, (7), p. 705-709.
Obst U et al, "Design of Novel, Nonpeptidic, Thrombin Inhibitors and Structure of a Thrombin-Inhibitor Complex," Angew.Chem.Int.Ed.Engl 1995, 34(16), p. 1739-1742.
Galley G. et al, "Polyfunctionalized Pyrrolidines by Stereoselective 1,3-Dipolar Cycloaddition of Azomethine Ylides to Chiral Enones," J.Org.Chem. 1995, 60, pp. 5005-5010.
Grigg G et al, "X=Y-ZH Systems as Potential 1,3-Dipoles-5.sup.1 --Intramolecular Cycloadditions of Imines of -Amino Acid Esters," Tetrahedron 1985, 41(17), p. 3547-3558.
Okamura H et al, "A Base Catalyzed Diels-Alder Reaction of 3-Hydroxy-2-Pyrone," Tetrahedron Lett 1995, 36(33), p. 5939-5942.
Grigg G et al, "X=Y-ZH Systems as Potential 1,3-Dipoles, Part 21.sup.1 Activation of the ZH Proton in Imines" Tetrahedron 1989, 45(6), p. 1723-1746.
Padwa A et al, "Studies on the Intramolecular Cycloaddition Reaction of Isomunchnones Derived from N-Alkenyl Substituted Diazoimides," Tetrahedron 1996, 52(9), p. 3247-3260.
Grigg G et al, "Decarboxylation of -Amino Acids by Pyruvic Acid and its Derivatives, Evidence for Azomethine Ylides in In Vitro Analogues of Pyruvoyl Enzymic Processes," Tetrahedron Lett 1989, 30(21), p. 2841-2844.
Okamura H et al, "Asymmetric Base-Catalyzed Diels-Alder Reaction of 3-Hydroxy-2-Pyrone with N-Methylmaleimide," Chem Lett 1996, (3), p. 193-194.
Amornraksa K et al, "X=Y-ZH Systems as Potential 1,3-Dipoles, Part 8, Pyrrolidines and -Pyrrolines (3,7-Diazabicyclo[3,3,0]octenes) from the Reaction of Imines of -Amino Acids and their Esters with Cyclic Dipolarophiles, Mechanism of Racemisation of -Amino Acids and the Esters in the Presence of Aldehydes," J.Chem.Soc.Perkin Trans 1 1987, 10, p. 2285-2296.
Harwood L et al, "Synthesis of Carboxylated Pyrrolidine Derivatives via 1,3-Dipolar Cycloadditions of Homochiral Double-Stabilised E-Azomethine Ylids," Tetrahedron Asymmetry 1995, 6(7), p. 1557-1560.
Ibata T. et al, "Carbonyl Ylide from 3-Chloro-3-p-nitrophenylcarbene and Acetone," Tetrahedron Lett 1986, 27(37), p. 4383.
Huisgen R et al, "Three-Component Reactions of Diazomalonic Ester, Benzaldehyde, and Electrophilic Olefins," J.Am.Chem.Soc 1982, 104, p. 4953-4954.
Miah S. et al, "Ligand Effects in the Rhodium(II) Catalysed Reactions of Diazoamides and Diazoimides," Tetrahedron 1996, 52(7), p. 2489-2514.
March P.et al, "Carbonyl Ylides from Aldehydes and Carbenes," J.Am.Chem.Soc 1982, 104, p. 4952.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Heterocycles as antimicrobial agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocycles as antimicrobial agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocycles as antimicrobial agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1726266

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.