Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-05-10
2000-05-16
Stockton, Laura L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514422, 514423, 514367, 514388, 514338, 5142282, 5142345, 514322, 5142338, 514314, 514307, 514375, 514253, 544135, 544139, 544 62, 544368, 544370, 546146, 546164, 546245, 546270, 546198, 5462734, 546197, 546199, 546152, 546139, 548525, 548526, 548537, 548518, 548178, 548164, 5483061, 548217, A61K 31445, C07D40512
Patent
active
060637951
ABSTRACT:
Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
REFERENCES:
patent: H725 (1990-01-01), Gordon
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4595407 (1986-06-01), Carter
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4634465 (1987-01-01), Ehrenfreund et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
patent: 5278148 (1994-01-01), Branca et al.
patent: 5776971 (1998-07-01), Getman et al.
Roberts et al., "Rational Design of Peptide-Based HIV Proteinase Inhibitors", Science, 248, 358-361, (1990).
Erickson et al., "Design, Activity, and 2.8 .ANG. Crystal Structure of a C.sub.2 Symmetric Inhibitor Complexed to HIV-1 Protease", Science, 249, 527-533 (1990).
Pearle et al., Nature, International Weekly Journal of Science, vol. 328, No. 6130, p. 482, Aug. 6-12, (1987).
Martin, "Ro 31-8959/003", Drugs of the Future, 16(3), 210-212 (1991).
Meek et al., "Inhibition of HIV-1 Protease in Infected T-lymphocytes by Synthetic Peptide Analogues", Nature, vol. 343, pp. 90-92 (1990).
McQuade, "A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation", Science, vol. 247, 454-456 (1990).
Rich et al., "Design of Protease Inhibitors", Peptide Inhibitors of Proteases, 511-520 (year not available).
Rosenberg et al., "Novel Renin Inhibitors Containing Analogues of Statine Retro-Inverted at the C-Termini: Specificity at the P.sub.2 Histidine Site", J. Med. Chem., 30, 1224-1228 (1987).
Fittkau, .alpha.-Aminochloromethylketone aus Aminosauren and Peptiden als substratanaloge Inhibitoren der Leucinaminopeptidase, Journal f. Prakt. Chemie, Band 315, Heft 6, S. 1037-1044 (1973).
Hirsch et al. "Therapy for Human Immunodeficiency Virus Infection", New England Journal of Medicine, vol. 328, No. 23, 1686-1695 (1993).
E.E. Gilbert, "Recent Developments in Preparative Sulfonation and Sulfation", Synthesis, International Journal of Methods in Synthetic Organic Chemistry, No. 1: Sep. (1969).
Mitsuya et al., "Inhibition of the in vitro Infectivity and Cytopathic Effect of Human T-lymphotrophic Virus Type III/Lymphadenopathy-Associated Cirus (HTLV-III/LAV) by 2',3'-Dideoxynulceosides", Prod. Natl. Acad. Sci. USA, vol. 83, 1911-15 Mar. (1986).
Silcox et al., "Benzodioxoles, Napthodioxins and Dibenzodioxepins", J. Heterocycl. Chem., 4, 166-67 (1967).
Cabiddu et al., "A Convenient Method for the Synthesis of 1,3-Benzoxathioles", Synthesis, 797-798 (1976).
Ncube et al., "Generation and Reactions of 2-Lithio-2-Substituted-1-3-Benzodithioles: New, Convenient Acyl Carbanion Equivalents", Tetrahedron Letters No. 26, 2345-2348 (1978).
Ncube et al., "A Convenient Synthesis of 2-Alkyl- and 2-Aryl-1,3-Benzodithioles", Tetrahedron Letters No. 3, 255-256 (1977).
Cole et al., "An Improved Method for the Synthesis of 2,2-Disubstituted and 2-Monosubstituted 1,3-Benzodioxoles", Aust. J. Chem., 33, 675-80 (1980).
Brown David L
DeCrescenzo Gary A
Devadas Balekudru
Freskos John N
Getman Daniel P
G.D. Searle & Company
Stockton Laura L.
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