Heterocycle-substituted diphosphonate compounds, pharmaceutical

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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546 22, 544243, 544337, C07F 96521, C07F 96509, A61K 31675

Patent

active

055190138

ABSTRACT:
The present invention relates to novel heterocycle-substituted diphosphonic acids, and the pharmaceutically-acceptable salts and esters thereof, in which the diphosphonate-substituted carbon atom moiety is attached to a carbon atom in a nitrogen-containing six membered ring heterocycle, preferably a piperidine ring. The heterocycle-substituted diphosphonic acid compounds have the general structure: ##STR1## wherein Z is a nitrogen-containing six membered ring heterocycle moiety selected from piperidinyl, diazinyl and triazinyl; m, n and m+n are from 0 to 10; Q is a covalent bond or a moiety selected from oxygen, sulfur or nitrogen; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are substituent groups.
The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.

REFERENCES:
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patent: 4687767 (1987-08-01), Bosies et al.
patent: 4696920 (1987-09-01), Bentzen et al.
patent: 4719203 (1988-01-01), Bosies et al.
patent: 4857513 (1989-08-01), Oku et al.

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