Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-02
1997-02-18
Gibson, Sharon
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544336, 546289, A61K 31495, C07D48702
Patent
active
056042302
ABSTRACT:
The present invention is concerned with antiretroviral (e.g. anti-HIV-1) compounds having the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently are halo or methyl; R.sup.3 is hydrogen, halo, nitro or trifluoromethyl; R.sup.4 is trifluoromethyl or methylcarbonyl; or a radical --C(.dbd.X)--NR.sup.5 R.sup.6 wherein X is O or S, and R.sup.5 and R.sup.6 each independently are hydrogen or C.sub.1-4 alkyl; or a radical --Alk--R.sup.7, wherein Alk is C.sub.1-4 alkanediyl; and R.sup.7 is hydrogen or hydroxy; Het is a heterocyclic radical of formula: ##STR2## Pharmaceutical compositions containing said compounds of formula (I) and processes of preparing said compounds and compositions.
REFERENCES:
patent: 3274190 (1966-09-01), Gray et al.
patent: 4246429 (1981-01-01), Van Daele
Bosmans Jean-Paul R. M. A.
Janssen Marcel A. C.
Janssen Paul A. J.
Van Daele Georges H. P.
Verdonck Marc G. C.
Gibson Sharon
Janssen Pharmaceutica N.V.
Metz Charles J.
Myers, Jr. Richard S.
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