Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-05-29
1994-10-25
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514326, 514394, 514397, 514398, 514399, 514400, 544139, 544370, 546210, 5483147, 5483201, 5483205, 5483191, 5483241, 540603, A61K 31535, A61K 31415, C07D41302, C07D26528, C07D23366, C07D23300
Patent
active
053589467
ABSTRACT:
This invention relates to imidazoles, namely, heterocycle-substituted amides, carbamates and ureas as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), pharmaceutical compositions containing them, and their use as antihypercholesterolemic and/or antiatherosclerotic agents for the treatment of atherosclerosis.
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Haust, M. D., Reaction Patterns of Intimal Mesenchyme To Injury, and Repair in Atherosclerosis, Adv. Exp. Med. Biol, 43, pp. 35-57 (1974).
Pike et al., Nutrition An Integrated Approach, 3rd Edition, John Wiley and Sons, Inc., New York, pp. 531-535 (1984).
Clarkson et al., Differences in Atherosclerotic Development, Annals of the New York Academy of Sciences, vol. 454, pp. 28-43 (1985).
Arner Raymond G.
Higel Floyd D.
The Du Pont Merck Pharmaceutical Company
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