Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Reexamination Certificate
2005-03-08
2005-03-08
Metzmaier, Daniel S. (Department: 1712)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
C525S404000, C528S425000, C528S491000, C528S492000, C528S495000, C568S486000, C568S613000, C568S497000
Reexamination Certificate
active
06864327
ABSTRACT:
This invention provides a method for preparing, in high purity and high yield, heterobifunctional derivatives of poly(ethylene glycol) or related polymers. A chromatographic purification step is not necessary in the method. In accordance with the method of the invention, an intermediate polymer having a formula of W-Poly-OH is provided bearing a removable group W at one terminus. The intermediate polymer W-Poly-OH is first altered by modifying the OH group to a first functional group X, followed by the removal of W to generate a second hydroxyl group. The latter hydroxyl group may then be further converted to a second functional group Y, thus providing the desired heterobifunctional derivative.
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Bentley Michael David
Harris J. Milton
Kozlowski Antoni
Alston & Bird LLP
Metzmaier Daniel S.
Nektar Therapeutics AL, Corporation
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